Effects of high- versus LOw-intensity lipid-lowering treatment in patients undergoing serial CoronAry compuTEd tomography angiography:Results of the multi-center LOCATE study
- Conditions
- I25Chronic ischaemic heart disease
- Registration Number
- DRKS00031954
- Lead Sponsor
- GRN-Klinikum Weinheim
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 216
Inclusion Criteria
Availability of images from at least 64-slice cardio-CT scanner.
Documentation of lipid-lowering therapy at time of serial cardio-CT scan.
Exclusion Criteria
Pregnancy/Lactation.
Patients without atherosclerotic lesions at baseline and follow-up.
Patients undergoing PCI or CABG between the 2 CCTA scans.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serial quantitative evaluation of plaque size and composition in patients with no/low versus moderate/high dose lipid-lowering therapy.
- Secondary Outcome Measures
Name Time Method Verification of results by analysis of inter- and intraobserver (>4 weeks) variability.