Comparative Effectiveness of Local Corticosteroid Injection and Open Surgical Release for Pain Outcomes in De Quervain Tenosynovitis: A Single-Centre Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Pain intensity - Visual Analog Scale (VAS)
研究概览
简要总结
This quasi-experimental study compared pain outcomes following local corticosteroid injection (CSI) versus open surgical release in 100 patients with clinically confirmed De Quervain tenosynovitis unresponsive to conservative management. Patients were allocated to treatment based on clinician judgment and patient preference. Pain was assessed using the Visual Analog Scale (VAS) at baseline, one month, and six months post-intervention. The study was conducted at a single tertiary care centre in Rawalpindi, Pakistan between March 2023 and April 2025.
详细描述
De Quervain tenosynovitis is a stenosing tendinopathy of the first dorsal extensor compartment of the wrist, causing radial-sided wrist pain. One hundred patients were enrolled and allocated to either corticosteroid injection (CSI; n=49) or open surgical release (n=51). The CSI protocol consisted of triamcinolone acetonide (40mg/mL, 1mL) combined with 1% lidocaine (1mL) injected into the first dorsal compartment under aseptic conditions. Surgical release involved longitudinal decompression of the fibro-osseous sheath overlying the APL and EPB tendons. The primary outcome was VAS pain score at baseline, one month, and six months. Statistical analysis included independent t-tests and linear mixed-effects modeling.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
VAS assessments at follow-up were performed by a trained assessor blinded to treatment allocation.
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of De Quervain tenosynovitis confirmed by positive Finkelstein test
- •Age 18-70 years
- •Pain sufficiently severe to impair activities of daily living
- •Failure to respond to at least 4 weeks of conservative management
排除标准
- •Concurrent inflammatory arthropathy (rheumatoid arthritis or gout)
- •History of prior wrist injury
- •Previous surgical or injection treatment for De Quervain tenosynovitis
- •Coexisting upper limb pathology (rotator cuff pathology, epicondylitis, or carpal tunnel syndrome)
结局指标
主要结局
Pain intensity - Visual Analog Scale (VAS)
时间窗: Time Frame: Baseline, 1 month, and 6 months post-intervention
Pain scored on a 0-10 VAS scale where 0 = no pain and 10 = worst imaginable pain, assessed by a blinded assessor
次要结局
- Adverse events(Throughout 6-month follow-up period)
研究者
Osama Ijaz
Post-graduate resident Trauma & Orthopedics
Rawalpindi Teaching Hospital, District Headquarter Hospital, Rawalpindi