Coronary Artery Plaque Characterisation with Non-invasive Multi-Slice Computed Tomography and Invasive Intravascular Ultrasound and Optical Coherence Tomography in Patients with Acute Coronary Syndromes Without ST-segment Elevatio

Completed

• Conditions: atherosclerosis; 10011082

• Registration Number: NL-OMON36442
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

- Chest pain suggestive for myocardial ischemia for at least 30 minutes;
- Electrocardiogram (ECG) with ST-segment shifts (ST-segment depression >1 mm in at least two contiguous leads or transient ST-segment elevation > 1mm with duration of < 30 min in at least two contiguous leads) and/or T-wave changes (T-wave inversion > 1.5 mm in at least three contiguous leads);
- Positive hs Troponin T > 14 ng/L or positive Troponin T <0.01 µg/L
- Clinical indication for invasive coronary angiography followed by PCI of the ischemia-related target lesion;
- Informed consent.

Exclusion Criteria

- Persistent ST-elevation of >1 mm in 2 or more leads;
- Need for emergency invasive coronary angiography and PCI;
- Need for emergency coronary artery bypass grafting;
- Presence of cardiogenic shock;
- Estimated glomerular filtration rate (eGFR) < 50 ml/min;
- Known allergy to iodine contrast agents;
- Cardiac rhythms other than sinus rhythm;
- Inability to lay supine;
- Inability tot sustain a breath-hold for 15 seconds;
- Inability to provide informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The accuracy of coronary plaque characterization with MSCT as compared to IVUS<br /><br>and OCT will be investigated. In addition, the correlation between plaque<br /><br>characteristics and clinical characteristics (gender and diabetes) will be<br /><br>explored.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>