Study of the Relation Between the Fat Infiltration of the Multifidus Muscle and the Lumbar Foraminal Stenosis, by 2D and 3D Segmentation

Completed

• Conditions: Degenerative Condition, Neurologic; Low Back Pain
• Interventions: Other: Spine surgery

• Registration Number: NCT06018155
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

The aim of this study is to evaluate the correlation between the fat infiltration of the lumbar multifidus muscle and several parameters including the severity of the lumbar foraminal stenosis. The investigators will analyse lumbar MRI of patients previously included in a database of patients suffering from low back pain. Foraminal stenosis, muscle fat infiltration and other imaging lumbar parameters will be studied by 2D and 3D manuel segmentation, semi-automatic segmentation. Correlations between factors influencing the muscle fat infiltration will be studied by univariate and multivariate statistical analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Study First Submitted: 2023-08-24
• Study First Submitted QC: 2023-08-24
• Study First Posted: 2023-08-30
• Primary Completion: 2023-09-01
• Study Completion: 2023-09-01
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-04
• Last Update Posted: 2025-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Single cohort	Spine surgery	Cohort of patients suffering from low back pain and candidate to a spine surgery included in a database previously constituted

Primary Outcome Measures

Name	Time	Method
Percentage of muscle fat infiltration	1 year	Muscle fat infiltration (%) will be evaluated by 3D segmentation analysis of T2 weighted lumbar spine MRIs

Secondary Outcome Measures

Name	Time	Method
Lumbar foraminal stenosis	1 year	Lumbar foraminal stenosis will be evaluated by 2D segmentation analysis of T2 weighted lumbar spine MRIs and expressed as a nerve/foramen surface ratio, and by the Lee et al. Classification

Trial Locations

Locations (1)

University Hospital of Nice; 🇫🇷 Nice, France