ROLE OF SPLENIC ELASTOGRAPHY FOR DIAGNOSIS OF PORTAL HYPERTENSION IN CHILDRE

Not Applicable

Conditions: Health Condition 1: null- Children less than 14 years with freshly diagnosed cases of Portal Hypertension confirmed by any of 4 parameters: Clinical/Radiological/Histological or Endoscopically

Registration Number: CTRI/2018/07/014929

Lead Sponsor: PGIMER

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

For Patients

1.All consecutive freshly diagnosed cases of Portal Hypertension confirmed by any of 4 parameters: Clinical/Radiological/Histological or Endoscopically

2.Age less than 14 years

For controls

1.Age and Sex matched controls <14 years

2.Healthy siblings of patients attending OPD/ IPD or patients with minor intercurrent illnesses

3.Children with body mass index within normal percentiles for age & sex

Exclusion Criteria

For Patients

1.Splenomegaly because of other etiologies- hematological/storage/infectious disorder

2.Patients of PHTN with splenectomy or after shunt surgery.

3.Patients receiving pharmacotherapy as primary or secondary prophylaxis

4.Patients receiving treatment for underlying liver disease viz., antivirals, steroids, d-penicillamine, anticoagulation etc.,

5.Patients too sick to be transported to the SWE suite

For Controls

1.Children with liver disease

2.Abnormal gray-scale US imaging

3.Presence of splenomegaly because of any cause

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ability of Spleen Stiffness Measurement (SSM) using Shear Wave Elastography (SWE) technique to predict the presence of Portal Hypertension and Varices In Children with liver diseases of different etiologiesTimepoint: At time of enrollment

Secondary Outcome Measures

Name	Time	Method
1.To study whether SSM differs according to etiology of Portal Hypertension (Prehepatic, Hepatic And Post Hepatic), in children with liver disease <br/ ><br>2.To study whether combining Liver Stiffness with Splenic Stiffness as determined by SWE improves the predictive ability to diagnose Portal Hypertension and Varices, in children with liver diseases <br/ ><br>3. To suggest normal values of splenic stiffness determined by SWE in healthy children (controls) <br/ ><br>Timepoint: At time of enrollment