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Clinical Trials/NCT04436848
NCT04436848UnknownNot Applicable

Identifying Leucocyte and Urine Biomarkers in Parkinson's Patients With LRRK2 G2385R Gene Variant

University of Malaya1 site in 1 country150 target enrollmentStarted: June 1, 2020Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Enrollment
150
Locations
1
Primary Endpoint
Identification of monocyte-based biomarkers for LRRK2 G2385R variant
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor (MLi-2) on these biomarkers, using immunoblotting and mass spectrometry.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Diagnosis of Parkinson's disease assigned by a movement disorder specialist according to clinical diagnostic criteria
  • •Age above 18 year-old
  • •Provision of a written informed consent

Exclusion Criteria

  • •Physical or mental incapacity to complete study protocol

Outcomes

Primary Outcomes

Identification of monocyte-based biomarkers for LRRK2 G2385R variant

Time Frame: Two years

Identification of urine-based biomarkers for LRRK2 G2385R variant

Time Frame: Two years

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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