Early Beta blocker Administration before reperfusion in patients with ST-Elevation Myocardial Infarction who are planned to undergo primary PCI.
Recruiting
- Conditions
- Acute Myocardioal infarction, rescue PCI, prehospital treatment.Myocard infarktHartinfarkt
- Registration Number
- NL-OMON24992
- Lead Sponsor
- Maatschap Cardiologie Isala klinieken Zwolle
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 408
Inclusion Criteria
1. Patients ≥ 18 years of age with symptoms of acute ST-elevation myocardial
infarction of more than 30 min but less than 12 hours and on the ECG ST-segment
elevation of ≥0.1 mV in two adjacent limb electrocardiograph (ECG) leads and
≥0.2 mV in two adjacent precordial ECG leads or new left bundle branch block
(LBBB).
Exclusion Criteria
1. Severe Hypotension (systolic blood pressure < 100 mmHg)
2. Cardiogenic shock (severe dyspnoea, hypotension and oxygen saturation
<92%, systolic blood pressure < 100 mmHg and heartrate > 110/min)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Infarct size as measured by MRI 1 month post MI.
- Secondary Outcome Measures
Name Time Method 1. Troponin-T after 24 hour of hospitalization<br /><br>2. Peak CK within hospitalization period<br /><br>3. Area under CK and CK-MB curve within hospitalization period.<br /><br>4. Residual ST deviation 1 hr after CAG/PCI<br /><br>5. Ventricular Fibrillation requiring defibrillation during transportation and hospitalization<br /><br>6. MACE at 30 days and one year FUP<br /><br> <br /><br>Safety End Points:<br /><br>1. The incidence of severe bradycardia, asthma or cardiogenic shock<br /><br>2. 30 day and one year total mortality