Efficacy Of Triphaladi Kwatha And Mustadi Kwatha In The Management Of Dyslipidemia- An Open Labeled Randomized Clinico- Comparative Study

·       Inthis study, total 30 patients were registered and all patients had completedtreatment along with follow- up.

·     In this study, maximum 50 % i.e., 15 patients werebelonging to the age group of 45-65 years followed by 36.66 % i.e., 11patients were belonging to 31-45 yearsage group,13.33 % to 18- 30 years of age group.

·     In this study 50 % patients were females and rest 50 % patientswere males among the registered 30 patientsof Dyslipidemia.

·     In this study maximum numbers of patientsi.e., 93.33 % were from Hindu community, whereas 6.66 % patients were from Muslim community.

·     In the present study maximum numbers of patientsi.e., 90 % were from Urban Locality, whereas 10 % patients were from rurallocality.

·     In the present study 96.66 % of patients were married,whereas 3.33 % patients were unmarried.

·      In the present study maximum 56.66 % patients werehaving education till graduation, 20 % were having education HSC, 23.33 % werehaving education till Post Graduate.

·     In the present study socio-economically 36.66 % patients were from upper middleclass, 63.33 % were lower middle class.

·      In the present study 43.33 % patients were housewife, 43.33% were doingservice, 13.33 % were having business.

·   In the present study 25 patients(83.34 %) had Sedentary habit, 15 patients (50%)had menopause aggravating factors.

·   In the present study 11patients (36.66 %) had positive previous drug history, 19 (63.33%) had negative drug history.

·   In the present study 7 patients(23.33 %) had positive previous family history,23 (76.66 %) had negative family history.

·      In the present study, minimumnumbers of patients were from Vata Pittaja Prakriti i.e., 6.66% patients were found, 36.66 % Pitta Kaphaja Prakriti & 56.66 % belongedto V**ata Kaphaja Prakriti.

·       In thepresent study 3.33% patients belong to Satvika Manasika Prakriti,whereas 96.66 % patients were of Rajasika Manasika Prakriti.

·       In thepresent study, 90% patients had MadhyamaSara, 3.33% were from Pravara Sara, and 6.66% were from Avara Sara.

·      In the present study, 83.33% patients were ofMadhyama Samhanana and 16.66% were from PravaraSamhanana.

·      In the present study, 93.33% patients were ofMadhyama Pramana and 6.66% were from Sama Pramana.

·       In thepresent study, maximum 73.33 % i.e., 11 patients showed Madhyama Satva, 20 % i.e., 3 patientshad Avara Satva while 6.66% were from Pravara Satva.

·      In the present study, maximum 96.66% i.e., 29 patients showed Madhyama Satmya, 3.33 % i.e., 1 patienthad Pravara Satmya.

·       In thepresent study, 6.66 % were having Pravara Abhyavaharana Shakti, 13.33 % had Avara, whereas80 % had Madhyama AbhyavaharanaShakti.

·       Inthe present study,maximum i.e., 24 (80%) patientsshowed Madhyam *Jarana Shakti,*4 (13.33 %) patients had Avara,whereas 1 patient i.e., (6.66 %) showed Prav**ara Jarana Shakti.

·      In the present study, maximum 20 patients(66.66 %) hadMadhyama *Vyayam Shakti ,*10 patients had (33.33 %) Avara Vyayama Shakti.

·      In the present study, maximum 21 patients(70 %) had Madhyama Koshtha, 1patient had (3.33 %) Mridu Koshtha while8 patients (26.66%) hadKrura Koshtha.

·      In the present study, maximum 18 patients(60 %) had Vishamagni, 06 patients(20 %) had Samagni, 04 (13.33 %)patients had Mandagni, while 2 (6.66%) patients had Tikshnagni out of 30 registered cases ofDyslipidemia*.*

·       Inthe present study, 24 (80 %) patients were taking vegetarian diet whereas 6 (20%) patients were taking mix diet among 30selected cases of Dyslipidemia.

·      In the present study, maximum i.e., 43.33% patients practiced Adhyashana, 30%patients practiced Vishamashana, 20 %patients showed habit of Samashana& 6.66 % patients practicedViruddhashan.

·       Inthe present study, 27 patients (90%) showed dominance of Madhur Rasa, 13(43.33%) patients showed Amla Rasa predominance, 20 patients showed Lavana Rasa predominance in (66.66 %),14 patients showed Katu Rasa predominance i.e., 46.66 %, no patient had TiktaandKashaya Rasa dominantin their diet.

·       Inthe present study, 23 patients (76.66 %) showed evidence of sound sleep, 08patients (26.66 %) showed evidence of excess sleeping habits, 1 patient (3.33%) showed habit of disturbed sleep.

·       Inthe present study, maximum 16 patients (53.33 %) had no habit of exercise and14 patients had habit of exercise (46.66 %).

·       Inthe present study, maximum 73.33 % patients had regular bowel habit and 26.66%patients had irregular/ constipated bowel habit.

·       Inthe present study, all the patients had Madhyama Mootra Pravriti.

·       Inthe present study,1 female patient had regular menstrual cycle (6.66%), 14female patients had menopause (93.33%).

·       Inthe present study, 18 patients had addiction of tea (60 %), 8 patients hadaddiction of coffee (26.66%), 2 patients had addiction of tobacco (6.66%).

·       Inthe present study, 36.66 % patient had SheetaGuna dominant, 93.33 % patients hadGuru Guna dominant, 90 % patients had Snigdha Guna dominant, 23.33 % had UshnaGuna dominant diet.

·       Inthe present study, maximum patients i.e., 29 (96.67 %) showed Godhuma Nidana Sevana, 28patients (93.34%) showed Dugdha Nidana Sevana, 27 (90 %)patients show Madhura and Guru Guna Nidana Sevana*.*

·      In the presentstudy, 25 (83.34 %) patients hadSukhashaiyasana**, 18 (60 %) patients had Diwaswapna, 16 (53.34%) patients had Avyayama*.*

·      In the presentstudy, 12 (50%) patients had Atichinta and15 *(*40%) patients had Harshanityatatva as Mansika Nidana.

·   In the presentstudy, 14 patients (46.67%) had height between 151-160 cms, 12 (40%) had height between161-170 cms, and 2 (6.67%) hadheight between 141-150 cms and 2 (6.67%) had height 171cms and above.

·      In the presentstudy, 17 patients (56.67%) had weight between 61-70 kgs, 9 (30%) had weightbetween 71-80kgs, 3 (10%) had weight between 51-60kgs and 1 (3.34%) had weightabove 90kgs

·In the presentstudy, 11patients (36.67 %) belonged to 25.0-27.0 kg/m2, 9 (30%) belonged to <25kg/m2, 7 (23.34%) belonged to 27.1-29.0 kg/m2, 2 (6.67%) belongedto 31.1-33.0 kg/m2   and 1 (3.34%) belonged to 29.1-31.0kg/m2 BMI.

·       In the present study, 40% of thepatients were having cholesterol <200mg/dl,followed by 33.34% having cholesterolbetween 200-239mg/dl & 26.67%of the patients were having cholesterol above 240mg/dl.

·       In the present study, 50% of thepatients were having serum triglyceride above 200mg/dl, followed by 33.33% having triglycerides levels below 150 mg/dl & 16.67% of the patients were having triglycerides in therange of 150-199mg/dl.

·      In the present study, 36.67% of the patients were having serum LDLless than 100mg/dl followed by 33.33%of the patients having serum LDL in the range of 100- 150mg/dl.26.67% of the patients having serum LDL in the range of 150- 190mg/dl & 3.34%patients were reported to have S.LDL more than 190mg/dl.

·      In the present study, 56.67% of the patients were having serum HDL inthe range of 40-60mg/dl followed by 36.67%of the patients were having S. HDL less than 40mg/dl and 6.67% of the patients were having the values above 60mg/dl.

·       In the present study, 40% of the patientswere having S. VLDL in the range of 20-40mg/dl followed by 23.33% of patients having S. VLDL less than 20 mg/dl. &20% of the patients having S. VLDL above 60mg/dl & 16.67% of the patients were having S. VLDL in therange of 40-60 mg/dl.

RESULTS

Resultsin Group A: - Triphaladi kwatha

In group A, highly significant resultswere observed in Alasya, Daurbalya, Atipipasa, Atinidra, Gatra Gaurav,Chala-Sphik-Udara-Stana, Atikshudha, Kshudra Shwas, Shithilangata weredecreased by 84.37%, 78.12%, 72.72%, 70.58%,70.58%, 50%, 60.71%,68.75%, 64.70% respectively. Significant results were observed in GatraDaurgandhya, Swedadhikya, Tandra, Angamarda and percentagewise decreased by50%, 58.82%,93.33%, 69.23% respectively.

In group A, highly significant resultswere observed in S. Total Cholesterol, S.Triglyceride, S.VLDL, S.HDL,WEIGHT, BMI and weredecreased by 10.25%, 20.89%, 14.94%, 14.42%, 4.54% and 4.53% respectively. Significantresults were observed in S. LDL and were decreased by 14.03%.

Resultsin Group B: - Mustadi kwatha

Inthe present study, in group B, highly significant results were observed in Chala-Sphik-Udara-Stana, Swedadhikya, Alasya, Daurbalya, Atinidra, Gatra Gaurav,Atikshudha, Tandra, Kshudra Shwasa, Angamarda, were decreased by 65.7%,64.70%, 85.71%, 86.11%, 66.66%, 80.55%, 62.5%, 62.96%, 88.88%, 73.33%respectively. Significant results were observed in Atipipasa, Gatra**Daurgandhya, Shithilangata were decreased by 71.42%, 57.142%,53.84% respectively.

In group B, highly significant resultswere observed in S. Total Cholesterol, S.Triglyceride, S.VLDL, S.HDL,WEIGHT, BMI and were decreased by 11.19%, 11.04 %, 16.88 %, 10.03 %, 3.84% and 3.87% respectively. Significant resultswere observed in S. LDL and were decreased by 14.03%.

OverallEffect of Therapies

•       In Group A: Mild Improvement was found in 13(86.66%), unchanged improvement was found in 2 (13.33%) patients.

•       In Group B: Moderate Improvement was found in 2(13.33%), Mild Improvement was found in 10 (66.66%), unchanged improvement wasfound in 3 (20%) of patients.

•       In Both Groups: Moderate Improvement was found in 2(6.66%), Mild Improvement was found in 23 (76.66%), unchanged improvement wasfound in 5 (16.66%) of

patients.

 DISCUSSION

The final section, titled discussion,includes brief description of the conceptual study, scientific interpretationof observations obtained, detailed description of the results and possible modeof action of treatment.