Remifentanil for Preventing Propofol Injection Pain in Elderly Patients
- Registration Number
- NCT03330782
- Lead Sponsor
- Ajou University School of Medicine
- Brief Summary
Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing injection pain during propofol induction in elderly patients by the Dixon's up-and-down method.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 52
- ASA physical status I or II undergoing general anesthesia
- neurologic disorder
- psychologic disorder
- vascular disorder
- patients with chronic pain
- difficulty in vascular access
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Elderly Remifentanil Remifentanil was infused at predetermined effect-site concentration before propofol infusion in elderly patients. Adult Remifentanil Remifentanil was infused at predetermined effect-site concentration before propofol infusion in adult patients.
- Primary Outcome Measures
Name Time Method Severity of propofol injection pain-4 point scale during 3 min after remifentanil and propofol infusion to reach the equilibrium of plasma and effect-site concentration 0 = no pain (negative response to questioning),
1. = mild pain (pain reported only in response to questioning without any behavioral signs),
2. = moderate pain (pain reported in response to questioning and accompanied by a behavioral signs or pain reported spontane¬ously without questioning),
3. = severe pain (vocal response accompanied by facial grimacing, arm withdrawal, or tears)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Jong Yeop Kim
🇰🇷Suwon, Gyeonggi-do, Korea, Republic of