Remifentanil for Smooth Emergence in Elderly Patients

Phase 4

Completed

• Conditions: Drug Usage
• Interventions: Drug: Remifentanil; Drug: Sevoflurane

• Registration Number: NCT02334046
• Lead Sponsor: Ajou University School of Medicine

Brief Summary

Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anaesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing cough during emergence in elderly patients under sevoflurane and remifentanil anesthesia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-01-06
• Study First Submitted QC: 2015-01-07
• Study First Posted: 2015-01-08
• Study Start: 2015-02
• Primary Completion: 2015-11
• Status Verified: 2015-12
• Study Completion: 2015-12
• Last Update Submitted: 2015-12-16
• Last Update Posted: 2015-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

• ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under balanced anesthesia with sevoflurane and remifentanil

Exclusion Criteria

• predicted difficult airway, body mass index > 30 kg/m2, history of obstructive sleep apnoea chronic respiratory disease or coughing, current smokers patients angiotensin converting enzyme-inhibitors

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Adult	Remifentanil	Remifentanil was maintained at predetermined effect-site concentration during the emergence period in adult patients.
Adult	Sevoflurane	Remifentanil was maintained at predetermined effect-site concentration during the emergence period in adult patients.
Elderly	Remifentanil	Remifentanil was maintained at predetermined effect-site concentration during the emergence period in elderly patients.
Elderly	Sevoflurane	Remifentanil was maintained at predetermined effect-site concentration during the emergence period in elderly patients.

Primary Outcome Measures

Name	Time	Method
Number of cough	from end of surgery to 5 min after tracheal extubation	Number of cough or a strong and sudden contraction of the abdomen during periextubation periods

Trial Locations

Locations (1)

Ajou University Hospital; 🇰🇷 Suwon, Gyeongki-do, Korea, Republic of