Effect-site Concentration of Remifentanil for Preventing Propofol Injection Pain in Elderly Patients: A Comparison With Adult Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Severity of propofol injection pain-4 point scale
研究概览
简要总结
Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing injection pain during propofol induction in elderly patients by the Dixon's up-and-down method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •ASA physical status I or II undergoing general anesthesia
排除标准
- •neurologic disorder
- •psychologic disorder
- •vascular disorder
- •patients with chronic pain
- •difficulty in vascular access
研究组 & 干预措施
Elderly
Remifentanil was infused at predetermined effect-site concentration before propofol infusion in elderly patients.
干预措施: Remifentanil (Drug)
Adult
Remifentanil was infused at predetermined effect-site concentration before propofol infusion in adult patients.
干预措施: Remifentanil (Drug)
结局指标
主要结局
Severity of propofol injection pain-4 point scale
时间窗: during 3 min after remifentanil and propofol infusion to reach the equilibrium of plasma and effect-site concentration
0 = no pain (negative response to questioning), 1. = mild pain (pain reported only in response to questioning without any behavioral signs), 2. = moderate pain (pain reported in response to questioning and accompanied by a behavioral signs or pain reported spontane¬ously without questioning), 3. = severe pain (vocal response accompanied by facial grimacing, arm withdrawal, or tears)
次要结局
未报告次要终点
研究者
Jong Yeop Kim
Professor
Ajou University School of Medicine