Effect-site Concentration of Remifentanil for Preventing Propofol Injection Pain in Elderly Patients: A Comparison With Adult Patients
Overview
- Phase
- Phase 4
- Intervention
- Remifentanil
- Conditions
- Drug Usage
- Sponsor
- Ajou University School of Medicine
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Severity of propofol injection pain-4 point scale
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing injection pain during propofol induction in elderly patients by the Dixon's up-and-down method.
Investigators
Jong Yeop Kim
Professor
Ajou University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •ASA physical status I or II undergoing general anesthesia
Exclusion Criteria
- •neurologic disorder
- •psychologic disorder
- •vascular disorder
- •patients with chronic pain
- •difficulty in vascular access
Arms & Interventions
Elderly
Remifentanil was infused at predetermined effect-site concentration before propofol infusion in elderly patients.
Intervention: Remifentanil
Adult
Remifentanil was infused at predetermined effect-site concentration before propofol infusion in adult patients.
Intervention: Remifentanil
Outcomes
Primary Outcomes
Severity of propofol injection pain-4 point scale
Time Frame: during 3 min after remifentanil and propofol infusion to reach the equilibrium of plasma and effect-site concentration
0 = no pain (negative response to questioning), 1. = mild pain (pain reported only in response to questioning without any behavioral signs), 2. = moderate pain (pain reported in response to questioning and accompanied by a behavioral signs or pain reported spontane¬ously without questioning), 3. = severe pain (vocal response accompanied by facial grimacing, arm withdrawal, or tears)