Effect-site Concentration of Remifentanil for Preventing Cough During Emergence in Elderly Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Number of cough
研究概览
简要总结
Elderly patients show different pharmacokinetic and pharmacodynamic variables and usually need smaller doses of anaesthetic drugs than younger patients. The purpose of this study was to investigate the optimal effect-site concentration of remifentanil for preventing cough during emergence in elderly patients under sevoflurane and remifentanil anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under balanced anesthesia with sevoflurane and remifentanil
排除标准
- •predicted difficult airway, body mass index > 30 kg/m2, history of obstructive sleep apnoea chronic respiratory disease or coughing, current smokers patients angiotensin converting enzyme-inhibitors
研究组 & 干预措施
Elderly
Remifentanil was maintained at predetermined effect-site concentration during the emergence period in elderly patients.
干预措施: Remifentanil (Drug)
Elderly
Remifentanil was maintained at predetermined effect-site concentration during the emergence period in elderly patients.
干预措施: Sevoflurane (Drug)
Adult
Remifentanil was maintained at predetermined effect-site concentration during the emergence period in adult patients.
干预措施: Remifentanil (Drug)
Adult
Remifentanil was maintained at predetermined effect-site concentration during the emergence period in adult patients.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Number of cough
时间窗: from end of surgery to 5 min after tracheal extubation
Number of cough or a strong and sudden contraction of the abdomen during periextubation periods
次要结局
未报告次要终点
研究者
Jong Yeop Kim
Associate professor
Ajou University School of Medicine