Combined Nutritional and Exercise Strategies to Reduce Liver Fat Content in Patients With Type 2 Diabetes

Federico II University0 sites45 target enrollmentSeptember 2009

ConditionsPostprandial Lipids Metabolism Type 2 Diabetes

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Postprandial Lipids Metabolism
Sponsor: Federico II University
Enrollment: 45
Primary Endpoint: Liver fat content
Status: Completed
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The aim of this study will be to evaluate in patients with type 2 diabetes the effects on liver fat of an intervention with a diet relatively rich in CHO/rich in fibre/low GI or a diet rich in MUFA, either combined or not with a structured program of physical exercise, with emphasis on mechanisms possibly underlining these effects, namely changes in postprandial triglyceride-rich lipoproteins, body fat distribution, insulin sensitivity, oxidative stress and inflammation, adipose tissue lipolytic activities, aerobic capacity and endothelial function.

Registry

clinicaltrials.gov

Start Date

September 2009

End Date

September 2011

Last Updated

13 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Federico II University

Responsible Party

Principal Investigator

rivellese angela

Federico II University

Eligibility Criteria

Inclusion Criteria

•Men and postmenopausal women
•Age 35-65 years
•BMI 27- 34 kg/m2
•HbA1c \<8%
•Fasting plasma cholesterol \<250 mg/dl
•Fasting plasma triglycerides \<300 mg/dl

Exclusion Criteria

•Hypolipidemic drugs
•Plasma creatinine \>1.7 mg/dl transaminases \> 2 norma values
•Ischemic heart disease or positive treadmill stress test
•High intensity regular physical activity
•Any disease or chronic or/and acute condition contraindicating physical activity(anaemia, and infectious, neoplastic, neurological and osteoarticular diseases).