Combined Nutritional and Exercise Strategies to Reduce Liver Fat Content in Patients With Type 2 Diabetes
Not Applicable
Completed
- Conditions
- Postprandial Lipids MetabolismType 2 Diabetes
- Registration Number
- NCT01025856
- Lead Sponsor
- Federico II University
- Brief Summary
The aim of this study will be to evaluate in patients with type 2 diabetes the effects on liver fat of an intervention with a diet relatively rich in CHO/rich in fibre/low GI or a diet rich in MUFA, either combined or not with a structured program of physical exercise, with emphasis on mechanisms possibly underlining these effects, namely changes in postprandial triglyceride-rich lipoproteins, body fat distribution, insulin sensitivity, oxidative stress and inflammation, adipose tissue lipolytic activities, aerobic capacity and endothelial function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
- Men and postmenopausal women
- Age 35-65 years
- BMI 27- 34 kg/m2
- HbA1c <8%
- Fasting plasma cholesterol <250 mg/dl
- Fasting plasma triglycerides <300 mg/dl
Exclusion Criteria
- Hypolipidemic drugs
- Plasma creatinine >1.7 mg/dl transaminases > 2 norma values
- Ischemic heart disease or positive treadmill stress test
- High intensity regular physical activity
- Any disease or chronic or/and acute condition contraindicating physical activity(anaemia, and infectious, neoplastic, neurological and osteoarticular diseases).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Liver fat content 0 and 8 weeks postprandial lipids metabolism 0 and 8 weeks
- Secondary Outcome Measures
Name Time Method changes in body fat distribution 0 and 8 weeks oxidative stress and inflammation 0 and 8 weeks adipose tissue lipolytic activities 0 and 8 weeks