Diet and Exercise in Type 2 Diabetes - a Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus, Type 2
- Sponsor
- Umeå University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Fat mass
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The investigators investigate if combined progressive aerobic training and resistance training improve metabolic control and fat mass in patients with type 2 diabetes who are eating a modified paleolithic diet. The investigators randomize 40 participants to two groups: 1) Modified paleolithic diet and exercise under observation 3 sessions/week, 2) Modified paleolithic diet and general advice about exercise.
The investigators primary hypothesis is that in patients with type 2 diabetes decreases fat mass more with progressive exercise under observation and a modified paleolithic diet than with general advice about exercise and a modified paleolithic diet.
Investigators
Tommy Olsson
Professor
Umeå University
Eligibility Criteria
Inclusion Criteria
- •type 2 diabetes less than 10 years
- •BMI 27-35
- •women only after menopause
- •diabetes treatment with diet and/or metformin
- •HbA1c between 45 and 94
Exclusion Criteria
- •nicotine use
- •betablockers
- •estrogens orally
- •blod pressure \>160/100
- •macroalbuminuria
- •malignancy during the past 5 years
- •alcoholism
- •depression
- •cardiovascular disease/stroke
- •liver disease
Outcomes
Primary Outcomes
Fat mass
Time Frame: Baseline - 12 weeks
Measured with DEXA (dual energy x-ray absorptiometry)
Secondary Outcomes
- Hepatic insulin sensitivity(Baseline - 12 weeks)
- Appetite regulation(Baseline - 12 weeks)
- Dopamine 2-receptors in striatum(Baseline - 12 weeks)
- Anaerobic Threshold(Baseline - 12 weeks)
- Substrate utilization during submaximal exercise(Baseline - 12 weeks)
- Liver fat(Baseline - 12 weeks)
- Cortisol turnover(Baseline - 12 weeks)
- Executive ability and memory(Baseline - 12 weeks)
- Validity of energy intake and protein intake(Baseline - 6 weeks - 12 weeks)
- Oxygen Uptake(Baseline - 12 weeks)
- Peripheral insulin sensitivity(Baseline - 12 weeks)
- Experience of training(Baseline - 12 weeks)