Exercise Training and Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Glycemic Control
研究概览
简要总结
The purpose of this study is to assess whether 4-months of interval-walking exercise training improves glycemic control in individuals with type 2 diabetes mellitus. The effects of interval-walking training will be compared to continuous-walking exercise in a randomised, controlled trial design. Changes in glycemic control will be examined using oral glucose tolerance tests (OGTT) with stable isotope methodology. In addition, insulin sensitivity and secretion will be examined using glucose clamps combined with glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18 to 80
- •normal glucose tolerance, impaired glucose tolerance, or type 2 diabetes (as evidenced by use of oral hypoglycemic medication or 2-hour OGTT glucose > 11.1 mmol/l)
排除标准
- •Insulin treatment or type 1 diabetes
- •BMI <19 or >40
- •Physically active
- •Undergoing weight-loss/gain
- •Pregnancy
- •Contraindication to exercise (ECG/CPX)
- •Significant cardiovascular disease
- •History of renal/hepatic/gastrointestinal/pulmonary disease
- •Clotting or bleeding disorders
结局指标
主要结局
Glycemic Control
时间窗: 0 and 4 months
Fasting glucose, two-hour glucose during OGTT, and hemoglobin A1c will be measured.
次要结局
- Beta-cell Function(0 and 4 months)
- Body Composition(0 and 4 months)
研究者
Thomas Solomon
Group Leader
Rigshospitalet, Denmark