Exercise Training and Type 2 Diabetes
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 32
- Locations
- 2
- Primary Endpoint
- Glycemic Control
Study Overview
Brief Summary
The purpose of this study is to assess whether 4-months of interval-walking exercise training improves glycemic control in individuals with type 2 diabetes mellitus. The effects of interval-walking training will be compared to continuous-walking exercise in a randomised, controlled trial design. Changes in glycemic control will be examined using oral glucose tolerance tests (OGTT) with stable isotope methodology. In addition, insulin sensitivity and secretion will be examined using glucose clamps combined with glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age 18 to 80
- •normal glucose tolerance, impaired glucose tolerance, or type 2 diabetes (as evidenced by use of oral hypoglycemic medication or 2-hour OGTT glucose > 11.1 mmol/l)
Exclusion Criteria
- •Insulin treatment or type 1 diabetes
- •BMI <19 or >40
- •Physically active
- •Undergoing weight-loss/gain
- •Pregnancy
- •Contraindication to exercise (ECG/CPX)
- •Significant cardiovascular disease
- •History of renal/hepatic/gastrointestinal/pulmonary disease
- •Clotting or bleeding disorders
Outcomes
Primary Outcomes
Glycemic Control
Time Frame: 0 and 4 months
Fasting glucose, two-hour glucose during OGTT, and hemoglobin A1c will be measured.
Secondary Outcomes
- Beta-cell Function(0 and 4 months)
- Body Composition(0 and 4 months)
Investigators
Thomas Solomon
Group Leader
Rigshospitalet, Denmark