Physiological Response to Salbutamol and Exercise
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- University of Copenhagen
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Maximal oxygen consumption (VO2max)
Study Overview
Brief Summary
The scope of the study is to investigate the physiological response to salbutamol and exercise. A particular focus is on the metabolic response and amine metabolism.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •VO2max of >55 ml/min/kg for men and >50 ml/min/kg for women
- •Body mass index (BMI) < 26
Exclusion Criteria
- •Chronic use of beta2-agonist or allergy towards beta2-agonist
- •Serious adverse effects to beta2-agonist
- •Chronic disease deemed by the study responsible medical doctor to interfere with any part of the study
- •Chronic use of prescription medicine deemed by the study responsible medical doctor to interfere with any part of the study
- •Pregnancy (for women)
Arms & Interventions
beta2-agonist and exercise
Subjects undergo exercise training with administration of salbutamol (800 microgram in 12 hours x 2)
Intervention: salbutamol (Drug)
beta2-agonist and exercise
Subjects undergo exercise training with administration of salbutamol (800 microgram in 12 hours x 2)
Intervention: exercise (Other)
placebo and exercise
Subjects undergo exercise training with administration of sham placebo
Intervention: exercise (Other)
Outcomes
Primary Outcomes
Maximal oxygen consumption (VO2max)
Time Frame: Baseline, 2 weeks, 4 weeks and 6 weeks
Change in VO2max (measured during bike ergometer cycling to exhaustion)
Body composition
Time Frame: Baseline, 2 weeks, 4 weeks and 6 weeks
Change in body composition (measured by dual energy x ray absorptiometry)
Secondary Outcomes
- Salbutamol urine concentration(Before (baseline) as well as 0-1 hours, 1-2 hours, 2-4 hours, 4-8 hours, and 8-16 hours after administration)
Investigators
Morten Hostrup, PhD
Associate Professor
University of Copenhagen