Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a Functional Near-Infrared Spectroscopy Device During Usual Walking: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- oxygenated hemoglobin (HbO2) of the prefrontal regions,
研究概览
简要总结
Investigators investigate the patterns of cortical activation using the NIRST in patients with peripheral neurological injury caused by lower extremity burns.
详细描述
Understanding the mechanisms associated with locomotor networks may be of benefit for rehabilitation of burn victims with neurological locomotor deficits. However, the effects of peripheral neurological injury on locomotor network remains unknown. A wearable functional near-infrared spectroscopy (fNIRS) device has been developed for studying cortical hemodynamics. Changes in cortical activity has not previously been documented in patients with burn injury.
Investigators assessed 15 patients with lower extremity burns and 11 healthy controls.
Investigators measured walking-related cortical activity using an fNIRS device at baseline and during usual walking.
Cortical activity was measured by evaluating relative changes in oxyhemoglobin level. The NIRST Analysis Tool v2.1 was utilized to analyze fNIRS data in a MATLAB environment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •burn patients with lower extremity or upper extremity thermal injury
- •patients who could walk unassisted for at least 5min.
排除标准
- •patients with critical systemic conditions
- •severe cognitive impairment
- •had severe pain
- •unable to walk.
研究组 & 干预措施
burn injury and normal patient
HbO2 PFC perfusion using fNIRS
干预措施: Functional near-infrared spectroscopy (fNIRS) (Diagnostic Test)
结局指标
主要结局
oxygenated hemoglobin (HbO2) of the prefrontal regions,
时间窗: 5 minutes
identify the location of the normal cortical activation during usual walking
次要结局
未报告次要终点
研究者
So Young Joo
Department of Rehabilitation Medicine
Hangang Sacred Heart Hospital