Frontal Lobe Oxyhemoglobin Levels in Patients With Lower Extremity Burns Assessed Using a Functional Near-Infrared Spectroscopy Device During Usual Walking: A Pilot Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- oxygenated hemoglobin (HbO2) of the prefrontal regions,
Study Overview
Brief Summary
Investigators investigate the patterns of cortical activation using the NIRST in patients with peripheral neurological injury caused by lower extremity burns.
Detailed Description
Understanding the mechanisms associated with locomotor networks may be of benefit for rehabilitation of burn victims with neurological locomotor deficits. However, the effects of peripheral neurological injury on locomotor network remains unknown. A wearable functional near-infrared spectroscopy (fNIRS) device has been developed for studying cortical hemodynamics. Changes in cortical activity has not previously been documented in patients with burn injury.
Investigators assessed 15 patients with lower extremity burns and 11 healthy controls.
Investigators measured walking-related cortical activity using an fNIRS device at baseline and during usual walking.
Cortical activity was measured by evaluating relative changes in oxyhemoglobin level. The NIRST Analysis Tool v2.1 was utilized to analyze fNIRS data in a MATLAB environment.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •burn patients with lower extremity or upper extremity thermal injury
- •patients who could walk unassisted for at least 5min.
Exclusion Criteria
- •patients with critical systemic conditions
- •severe cognitive impairment
- •had severe pain
- •unable to walk.
Arms & Interventions
burn injury and normal patient
HbO2 PFC perfusion using fNIRS
Intervention: Functional near-infrared spectroscopy (fNIRS) (Diagnostic Test)
Outcomes
Primary Outcomes
oxygenated hemoglobin (HbO2) of the prefrontal regions,
Time Frame: 5 minutes
identify the location of the normal cortical activation during usual walking
Secondary Outcomes
No secondary outcomes reported
Investigators
So Young Joo
Department of Rehabilitation Medicine
Hangang Sacred Heart Hospital