A SEARCH TO IDENTIFY ANY DRUG-DRUG INTERACTION AMONG PSYCHIATRY INPATIENTS IN A TERTIARY HEALTHCARE CENTRE

Not yet recruiting

• Conditions: Other specified mental disorders due to known physiological condition,

• Registration Number: CTRI/2022/11/047051

Brief Summary

**INTRODUCTION:**

The term "drug-drug interaction" is an adverse drug event that can be defined as a process that occurs when two or more drugs are administered in such a way that can cause an interruption to the desired pharmacological activity of any of the administered drug thereby causing clinically undesirable changes to the drug’s action in a body.

**OBJECTIVE OF THE STUDY:**

To identify the potential drug-drug interactions among prescriptions of psychiatric inpatients and to detect any possible symptoms associated with these drug-drug interactions.

**METHODOLOGY:**

A prospective observational study will be conducted for a duration of 6 months among participants of either gender aged above 18 years with psychiatry disorder prescribed with at least two drugs(one of which is from the psychotropic class). A well designed data collection form will be used to collect the required data. Drug interaction will be identified using an appropriate software, Stockley’s drug interaction textbook.

**STATISTICAL ANALYSIS:**

Statistical analysis of the data will be done using SPSS 23.0 at 95% confidence level. Data will be expressed as descriptive statistics, meanS.D or frequency(%) and  will be analysed using Chi Square test to check for the association between patient demography and occurrence of pDDIs.

 **OUTCOME MEASURES:**

This study will help to determine the drugs associated with significant drug-drug interactions with respect to the severity and address the symptoms that accompanies them. The findings will serve as a guide for healthcare professionals by appraising the need for attention required to be given for possible and preventable drug-drug interactions that can occur among the psychiatric patients in the future.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-03-11
• Study Start: 2022-09-11

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 114

Inclusion Criteria

• Participants of either gender, age 18 years or above, admitted in the department of psychiatry, prescribed with at least two drugs(one of which was from the psychotropic class).
• All the participants with a psychiatric diagnosis as per the Tenth Revision of the International Classification of Diseases (ICD 10).

Exclusion Criteria

• Participants referred to the psychiatric unit for evaluation.
• Participants or guardian not willing to give consent.
• Topical agents and drugs which were not included in any of the reference resources.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to determine the drugs associated with significant drug-drug interactions and the symptoms related to them	baseline

Secondary Outcome Measures

Name	Time	Method
•The information from the results can be used by the healthcare workers for better understanding of drug-drug interactions occurring in the psychiatric patients and avoid the same in the future	Baseline

Trial Locations

Locations (1)

Justice KS Hegde Charitable Hospital, Nitte (Deemed to be University); 🇮🇳 Kannada, KARNATAKA, India

Justice KS Hegde Charitable Hospital, Nitte (Deemed to be University)

🇮🇳Kannada, KARNATAKA, India

Dr Juno J Joel

Principal investigator

9480470727

junojoel@nitte.edu.in