A Defined, Plant-based, 4-week Dietary Intervention Reduces Lp(a) and Other Atherogenic Particles
- Conditions
- Hypercholesterolemia
- Interventions
- Other: Dietary Intervention
- Registration Number
- NCT03172611
- Lead Sponsor
- Texas Woman's University
- Brief Summary
This study evaluates the effects of consuming a defined, plant-based diet on lipoprotein(a) and other atherogenic particles associated with cardiovascular disease risk.
- Detailed Description
Lipoprotein(a) is a carrier of oxidized low-density lipoprotein and is a particularly atherogenic biomarker. Lp(a) has been previously documented to be resistant to dietary therapies and its concentration is thought to be determined by genes. A plant-based diet has not been previously used in an attempt to influence the concentration of Lp(a).
Participants were instructed to follow a defined, plant-based dietary intervention for four weeks. All animal products were excluded. Cooked foods, free oils, soda, alcohol, and coffee were also to be excluded. All meals and snacks were provided to the participants for the full duration of the intervention. Emphasized were raw fruits and vegetables, while seeds, avocado, raw oats, raw buckwheat, and dehydrated foods were prepared as condiments. Vitamin, herbal, and mineral supplements were to be discontinued unless otherwise clinically indicated. Participants were not advised to alter their exercise habits.
Serum biomarkers were obtained from participants at baseline and after 4-weeks.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
- Body Mass Index ≥25.0 kg/m^2
- Serum low-density lipoprotein cholesterol concentration ≥100
- Systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90
- Tobacco use
- Drug abuse
- Excessive alcohol consumption (>2 glasses of wine or alcohol equivalent per day for men or >1 glass of wine or alcohol equivalent for woman)
- Current cancer diagnosis
- Estimated glomerular filtration rate <60 mg/dL
- Clinically defined infection
- Mental disability
- Hospitalization <6 months
- Previous exposure to plant-based diet
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Plant-based diet Dietary Intervention A defined, plant-based diet was prescribed for 4 weeks.
- Primary Outcome Measures
Name Time Method Change in serum lipoprotein(a) Baseline and 4-weeks Serum Lp(a) (nmol/L) was documented at baseline and after 4-weeks
- Secondary Outcome Measures
Name Time Method Change in serum total cholesterol Baseline and 4-weeks Serum total cholesterol (mg/dL) was documented at baseline and after 4-weeks
Change in serum low-density lipoprotein cholesterol Baseline and 4-weeks LDL cholesterol (mg/dL) was documented at baseline and after 4-weeks
Change in serum high-density lipoprotein cholesterol Baseline and 4-weeks Serum HDL (mg/dL) was documented at baseline and after 4-weeks
Change in serum high-density lipoprotein 2 cholesterol Baseline and 4-weeks Serum HDL2-C (mg/dL) was documented at baseline and after 4-weeks
Change in serum apolipoprotein A-1 Baseline and 4-weeks Serum Apo A-1 (mg/dL) was documented at baseline and after 4-weeks
Change in serum apolipoprotein-B Baseline and 4-weeks Serum Apo-B (mg/dL) was documented at baseline and after 4-weeks
Change in serum low-density lipoprotein particles Baseline and 4-weeks Serum LDL-P (nmol/L) was documented at baseline and after 4-weeks
Change in serum small-dense low-density lipoprotein cholesterol Baseline and 4-weeks Serum sdLDL-C (mg/dL) was documented at baseline and after 4-weeks
Trial Locations
- Locations (1)
Montgomery Heart & Wellness
🇺🇸Houston, Texas, United States