Clinical evidence-based study of Fuyuan Huoxue Decoction combined with extramedullary positioning osteotomy for prevention and treatment of deep vein thrombosis after total knee arthroplasty
- Conditions
- Knee Osteoarthritis
- Registration Number
- ITMCTR2024000071
- Lead Sponsor
- Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine, Huajiadi Street, Chaoyang District, Beijing
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) 50 years old = Enrollment age = 80 years old;
(2) Those who meet KOA diagnosis and TKA surgical treatment indications;
(3) No history of thrombosis related diseases within six months;
(4) For first-time unilateral TKA without contraindications for implantation;
(5) Color ultrasound examination of both lower limbs before surgery to exclude patients with thrombosis;
(6) Able to cooperate in completing follow-up visits and have good compliance;
(7) Voluntarily participate in this experiment and sign an informed consent form in writing.
(1) Those who do not meet the inclusion criteria;
(2) Individuals with severe internal medicine underlying diseases, including heart and lung dysfunction, severe liver and kidney dysfunction, or bone marrow hematopoietic dysfunction;
(3) Patients with abnormal coagulation function;
(4) Individuals with allergic constitution or those who are allergic to the drugs involved in this experiment;
(5) Patients with a history of gastrointestinal bleeding and a tendency to bleed;
(6) Patients with severe mental illnesses;
(7) Individuals who have participated in clinical trials of other investigational drugs or devices within the past three months;
(8) Other researchers believe that it is not suitable for this clinical study.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ltrasound examination of both lower limbs;
- Secondary Outcome Measures
Name Time Method inflammatory cytokines;Lower limb circumference;visual analogue scale;coagulation index;hospital for special surgery knee score;