Effects of Gene Polymorphisms on Metabolic Features in Clozapine-treated Patients With Schizophrenia
- Conditions
- SchizophreniaSchizoaffective Disorder
- Registration Number
- NCT01324167
- Lead Sponsor
- Taipei Medical University WanFang Hospital
- Brief Summary
The investigators would like to know the association of gene polymorphisms and metabolic adversities in clozapine-treated patients with schizophrenia in Taiwan.
- Detailed Description
The atypical antipsychotics, such as olanzapine, risperidone, quetiapine, and ziprasidone, are effective in treating both the positive and negative symptoms in schizophrenia (Kelleher et al., 2002). However, atypical antipsychotics have been linked to several forms of morbidity, including obesity, hyperlipidemia, and type 2 diabetes mellitus (DM) (Bergman and Ader, 2005; Jin et al., 2004; Melkersson and Dahl, 2004). Compared with the general population, life expectancy in schizophrenic patients is shorter by as much as 20%, attributable to higher rates of suicide, accidental deaths, and natural causes such as cardiovascular disease and DM (Harris and Barraclough, 1998). Several studies have suggested that these metabolic abnormalities may lead to a greater vulnerability to cardiovascular disease and thus may contribute to the excessive mortality among schizophrenic patients.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- fulfilled DSM-IV criteria of schizophrenia or schizoaffective disorder
- 18-65 year of age
- receiving clozapine for at least 6 months
- diabetes mellitus patients
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Taipei Medical University-WanFang Hospital
🇨🇳Taipei, Taiwan