Can We Alter Risk Factors For Oesophageal Cancer With Exercise?

Not Applicable

Completed

• Conditions: Barrett's Oesophagus; Oesophageal Adenocarcinoma prevention; Diet and Nutrition - Obesity; Physical Medicine / Rehabilitation - Physiotherapy; Cancer - Oesophageal (gullet)

• Registration Number: ACTRN12609000401257
• Lead Sponsor: Burns, Trauma and Critical Care Research Centre, School of Medicine, University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-06-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 120

Inclusion Criteria

Barrett's Oesophagus confirmed via the presence of intestinal metaplasia on biopsy and an abnormal appearance of the distal oesophagus via endoscopy.
Overweight or obese (Body mass index 25-34.99kg/m2)
Performing less than 60 min of moderate-intensity exercise per week for the previous 12 weeks.
No loss or gain of >5kg of body weight during the previous 6 months.

Exclusion Criteria

Serious medical impairments including: heart disease, lung disease, neurological disease, uncontrolled hypertension, diabetes, cancer, orthopaedic injuries.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum concentrations of the adipocytokines leptin and adiponectin analysed via radioimmunoassay. Blood samples will be fasting and obtained via venipuncture.[week 0, week 12, week 24];Serum concentrations of the inflammatory cytokines: C-Reactive Protein, Tumour Necrosis Factor-Alpha and Interleukin-6 will be analysed via immunoassay from fasting blood samples, obtained via venipuncture.[week 0, week 12, week 24];Fasting serum insulin and plasma glucose concentrations will be used to measure insulin resistance using the Quantitative Insulin Sensitivity Check Index (QUICKI) and the Reciprocal Index of Homeostasis Model Assessment (HOMA-IR) algorithms.[week 0, week 12, week 24]

Secondary Outcome Measures

Name	Time	Method
Gastro-oesophageal reflux symptoms using the Gastro-oesophageal Reflux Disease Impact Scale (GIS)[week 0, week 12, week 24];Bio-impedance analysis will measure body fat percentage, body fat mass and fat free mass. Waist to hip ratio and body mass index will also be measured to determine adiposity.[week 0, week 12, week 24];Muscular strength with be measured via the One Repetition Maximum (1RM) test performed on the bench press and leg press.[week 0, week 12, week 24];Peak oxygen uptake (VO2 peak) will provide a measure of cardiovascular fitness. VO2 peak will be measured via a portable metabolic analyser whilst the participant performs the Modified Shuttle Walk Test.[week 0, week 12, week 24]