Platelet transfusions in neonates

Recruiting

• Conditions: 10035534; thrombocytopenia

• Registration Number: NL-OMON36168
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 76

Inclusion Criteria

- Neonates, <28 days postnatal age, admitted to the neonatal or pediatric intensive care (NICU/PICU) with thrombocytopenia that require a platelet transfusion according to the clinical guidelines.
- Written informed consent by parent(s) or caregiver(s).

Exclusion Criteria

- Neonatal allo-immune thrombocytopenia (NIATP)
- Maternal ITP
- Therapeutic platelet transfusion during surgery
- Platelet transfusion during red blood cell exchange.
- Platelet transfusion during extracorporal membrane oxygenation (ECMO).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess recovery, estimated by platelet transfusion increment at 1 hour and<br /><br>24 hour.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. To assess the safety (bleeding / thrombotic complications / adverse<br /><br>transfusion reactions).<br /><br>2. To assess the transfusion interval, estimated as interval to next<br /><br>transfusion.<br /><br>3. To assess the donor exposure.</p><br>