Von Willebrand Antigen and Activity as Novel Biomarkers of Hemostasis in Inflammatory Bowel Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- detection of arterial or venous thrombosis
研究概览
简要总结
The investigators are going to study von Willebrand antigen and activity levels in patients with inflammatory bowel disease. The study will be on 46 patients who were diagnosed with inflammatory bowel disease mainly ulcerative colitis and Crohn's disease divided into two arms; group A will include 23 cases with active IBD(cases)status and group B will include 23 cases with inactive IBD status(control) to compare the vWF antigen and activity ( expected to be higher in active disease group.
The investigators will follow all of the patients for any arterial or venous thrombosis to evaluate IBD as a risk factor of thrombosis, on the other hand, they are looking to detect cases of acquired von Willebrand syndrome in some cases with bleeding that not explained by the inflammatory bowel disease status.
The aim of the work:
- Assessment of VWF antigen in patients with inflammatory bowel disease and correlate it to disease activity.
- Evaluation of VWF antigen as a risk factor for thrombosis in inflammatory bowel disease patients.
- Detection of acquired von Willebrand disease in inflammatory bowel disease.
详细描述
VWF is a high-molecular-weight multimeric glycoprotein, synthesized and released by vascular endothelial cells and megakaryocytes that play an important role in platelet-endothelial cell interaction and stabilizing the factor VIII (FVIII) coagulation protein.
Von Willebrand factor (VWF) is an acute-phase protein and a marker of endothelial damage.
VWF is crucial for platelet adhesion and aggregation. High-molecular weight multimers (HMWMs) are involved in platelet aggregation under high shear stress but under normal conditions it presents solely in the subendothelium and released into the bloodstream following activation of endothelial cells.
Coagulation and inflammation are simultaneously activated and respond in synergy as a preserved mechanism to repair the injured areas during tissue damage.
This observation is particularly relevant in acute inflammatory diseases, such as sepsis, but it also seems to be very important in chronic inflammatory conditions, such as inflammatory bowel disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with inflammatory bowel disease either newly or previously diagnosed aged18 years and older.
排除标准
- •Pregnancy.
- •Myocardial infarction.
- •Thromboembolism.
- •Known hemorrhagic diathesis.
- •Renal insufficiency.
- •Liver injury.
- •Diabetes.
- •patients who are on aspirin, heparin, oral anticoagulants, or oral contraceptives pills.
结局指标
主要结局
detection of arterial or venous thrombosis
时间窗: follow up for one year
all patients will be followed for detection of any thrombotic events to evaluate the thrombotic risk in IBD
comparison of von willebrand antigen and activity between the two groups
时间窗: baseline
Assessment of von willebrand antigen level as an activity marker in inflammatory bowel disease patients.
detection of acquired von willebrand syndrome
时间窗: follow up for one year
All patients who have bleeding not explained by the IBD status will be investigated for detection of any cases of acquired von willebrand syndrome.
次要结局
- Estimation of the prevalence of IBD patients attending our clinic (Assiut University Experience).(one year)
研究者
Alaa Mohammed Abozied Abdallah
clinical hematology specialist
Assiut University