Assessment of Right Ventricular Function in Patient With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mitral Stenosis
- Sponsor
- Assiut University
- Enrollment
- 30
- Primary Endpoint
- To compare RV function before and after PTMC
- Status
- Not Yet Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function
Detailed Description
In patients with mitral valve stenosis, right ventricular failure may develop either by the rheumatic process directly or through hemodynamic alterations resulting from pulmonary vascular changes. Right ventricular (RV) function plays an important role in development of clinical symptoms and prognosis in patients with mitral stenosis (MS).This is primarily affected by hemodynamic effects on RV due to pulmonary hypertension(PH). In the last two decades, Percutaneous Transluminal Mitral Commissurotomy (PTMC) has become the treatment of choice for patients with symptomatic rheumatic MS . Using this method,Mitral Valve Area (MVA) can be increased, which can improve the hemodynamic and clinical features of patients with MS . RV functional assessment is difficult and not done routinely because of its complex anatomy and high load dependence. Different modalitis are used to assess RV function as Tissue Doppler and two-dimensional (2D) speckle tracking method has been used to quantify strain for assessment Myocardial strain is a measure of tissue deformation, which is expressed as a percentage change.
Investigators
Yassmin Zakaria Basheir
Assessment of right ventricular function in patient with severe mitral stenosis before and after balloon mitral valvuloplasty
Assiut University
Eligibility Criteria
Inclusion Criteria
- •Patient with isolated mitral stenosis (except those with mild mitral regurgitation and are candidate for PTMC by 2D Echo evaluation).
- •Patient with normal left ventricular EF.
- •patient with sinus rhythm or AF
- •patient with any degree of pulmonary HTN
Exclusion Criteria
- •Patient with another valve lesion or more than mild mitral regurgitation.
- •Patient with impaired cardiac function.
- •patient with coronary arteries disease
- •Mitral stenosis of other etiology than rheumatic origin.
Outcomes
Primary Outcomes
To compare RV function before and after PTMC
Time Frame: 1 year
echocardiogram
Secondary Outcomes
- To measure the right side pressure changes invasively before and after PTMC(1 year)
- To compare the effect of PTMC on RV function in patient with AF and sinus rythm(1year)