Assessment of Right Ventricular Function in Patient With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 主要终点
- To compare RV function before and after PTMC
研究概览
简要总结
To detect short-term impacts of successful balloon mitral valvuloplasty on right ventricular function
详细描述
In patients with mitral valve stenosis, right ventricular failure may develop either by the rheumatic process directly or through hemodynamic alterations resulting from pulmonary vascular changes.
Right ventricular (RV) function plays an important role in development of clinical symptoms and prognosis in patients with mitral stenosis (MS).This is primarily affected by hemodynamic effects on RV due to pulmonary hypertension(PH).
In the last two decades, Percutaneous Transluminal Mitral Commissurotomy (PTMC) has become the treatment of choice for patients with symptomatic rheumatic MS . Using this method,Mitral Valve Area (MVA) can be increased, which can improve the hemodynamic and clinical features of patients with MS .
RV functional assessment is difficult and not done routinely because of its complex anatomy and high load dependence.
Different modalitis are used to assess RV function as Tissue Doppler and two-dimensional (2D) speckle tracking method has been used to quantify strain for assessment Myocardial strain is a measure of tissue deformation, which is expressed as a percentage change.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with isolated mitral stenosis (except those with mild mitral regurgitation and are candidate for PTMC by 2D Echo evaluation).
- •Patient with normal left ventricular EF.
- •patient with sinus rhythm or AF
- •patient with any degree of pulmonary HTN
排除标准
- •Patient with another valve lesion or more than mild mitral regurgitation.
- •Patient with impaired cardiac function.
- •patient with coronary arteries disease
- •Mitral stenosis of other etiology than rheumatic origin.
结局指标
主要结局
To compare RV function before and after PTMC
时间窗: 1 year
echocardiogram
次要结局
- To measure the right side pressure changes invasively before and after PTMC(1 year)
- To compare the effect of PTMC on RV function in patient with AF and sinus rythm(1year)
研究者
Yassmin Zakaria Basheir
Assessment of right ventricular function in patient with severe mitral stenosis before and after balloon mitral valvuloplasty
Assiut University