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临床试验/NCT04580823
NCT04580823已完成不适用

Exogenous Ketone Salt on Heart and Kidney Ketone Metabolism Measured by Positron Emission Tomography

Université de Sherbrooke2 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2020年10月15日最近更新:
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适应症

试验速览

阶段
不适用
状态
已完成
入组人数
10
试验地点
2
主要终点
11C-Acetoacetate Heart Ketone uptake
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Participants will undergo 3 Positron Emission Tomography (PET) scans in 3 different conditions :

  1. Fasting without exogenous ketone salt
  2. Fasting with exogenous ketone salt supplement
  3. Post-Prandial with exogenous ketone salt supplement.

详细描述

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt with or without food intake in middle-aged adults. Participants will have 3 different PET scan to perform :

  1. Fasting without exogenous ketone salt
  2. Fasting with exogenous ketone salt supplement
  3. Post-Prandial with exogenous ketone salt supplement.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
None

入排标准

年龄范围
45 Years 至 64 Years（Adult）
性别
All
接受健康志愿者
是

入选标准

  • •Aged between 45 and 64
  • •Generally Healthy
  • •BMI between 18.5 and 27

排除标准

  • •All drugs taken on a daily basis
  • •Diabetes or pre-diabetes
  • •Digestive dysfunction
  • •Pregnancy or lactation
  • •Allergy to the supplement
  • •Participate in an intensive physical exercise training (more than three times a week)
  • •Being on a ketogenic diet or consumption of ketogenic supplement.
  • •More than 2 alcoholic beverages each day
  • •Any clinically significant anomaly in the blood profile
  • •Claustrophobia
  • •Being enrolled in another interventional research project or in a PET research project
  • •Unable to lie dorsally supine for at least 60 minutes

结局指标

主要结局

11C-Acetoacetate Heart Ketone uptake

时间窗: 60 minutes

Heart ketone uptake measured by PET scan

Cardiac Functions, telesystolic volume

时间窗: 60 minutes

telesystolic volume

11C-Acetoacetate Kidney ketone uptake

时间窗: 60 minutes

Kidney ketone uptake measured by PET scan

Cardiac Functions, telediastolic volume

时间窗: 60 minutes

telediastolic volume

Cardiac functions, ejection fraction

时间窗: 60minutes

Ejection fraction

次要结局

  • Plasma ketone(60 minutes)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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