The Influence of Kidney Graft Function on Beat-to-beat QT Interval Variability

Not Applicable

Completed

• Conditions: Kidney graft function at 1 year post-transplant; QT interval variability indices; Left ventricular mass; Sudden cardiac death; Renal and Urogenital - Kidney disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12609000878279
• Lead Sponsor: niversity Medical Center Ljubljana

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-03-31
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Kidney transplant recipients at 1 year post-transplant.

Stable sinus rhythm with normal atrioventricular conduction on standard electrocardiogram (ECG).

Absence of heart failure symptoms and signs.

Exclusion Criteria

Patients receiving any drugs that are known to influence the QT interval duration.

Clinical, ECG, and echocardiographic evidence of coronary artery disease.

Patients with diabetes mellitus.

Increment of serum creatinine >= 20% at any time during the preceding three months.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
QT interval variability indices assessed with electrocardiogram (ECG) in real-time:<br>- corrected QT interval (QTc), <br>- QT interval dispersion (QTd), <br>- standard deviation of normal-to-normal QT interval (SDNN (QT))<br>- root-mean-square of the successive QT interval difference (rMSSD (QT)),<br>- QT interval variability index (QTVI).[1 year post-transplant];Sudden cardiac death[10-year after transplant]

Secondary Outcome Measures

Name	Time	Method
eft ventricular mass and left ventricular mass index, assessed with echocardiogram.[1 year post-transplant]