跳至主要内容
临床试验/CTRI/2024/06/069384
CTRI/2024/06/069384招募中不适用

Evaluation of fluid overload in Septic patients admitted to intensive care unit with Combined Venous Excess Lung Ultrasound (VExLUS) Score

All India Institute of Medical Sciences Patna1 个研究点 分布在 1 个国家目标入组 93 人开始时间: 2024年7月5日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
93
试验地点
1
主要终点
Incidence of global fluid overload by measuring VExLUS score

研究概览

简要总结

Hemodynamic management in critically ill septic patients has been traditionally focused on maintaining adequate cardiac output and arterial blood pressure by relying on fluid administration along with vasopressor and inotropic support. However, administration of fluid may lead to venous congestion compromising the organ perfusion which can be overlooked as a hemodynamic parameter on clinical assessment, and could be of utmost importance in management. Point of care ultrasound (POCUS) at  bedside allows the clinician to assess the status of intravascular volume and rule out portal, intrarenal  and pulmonary fluid overload. The correlation of  modified lung ultrasound score and extravascular fluid is a well-known parameter for the assessment of the global fluid status of the patient. Adding a lung ultrasound score to VExUS grading is a novel concept. Lung ultrasound evaluates 6 different lung areas,looking at B lines and graded 0,1,2,3. VExUS protocol evaluates the amount of venous congestion in the abdominal organs, specifically by scanning the portal, hepatic, and intra-renal veins. Doppler interrogation of these vessels yields a specific pattern corresponding to a level of venous congestion: normal, mild, or severe. By combining   modified lung ultrasound score and  VExUS grading, might lead to improvement in the sensitivity of early  fluid overload detection.This is a kind of study to evaluate the VExLUS grades in earlier identification of fluid overload in septic patients.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Diagnosis of sepsis (consistent with surviving sepsis campaign guidelines 2021 and clinical indication to be admitted in ICU).

排除标准

  • Patients in hemodialysis program Patients with previously known conditions that interfere with portal Doppler assessments, namely liver cirrhosis, or severe tricuspid regurgitation with structural heart disease.
  • If any of these conditions are identified during the present episode, the patient would also be excluded.
  • Age less than 18 years Patients subjected to withdrawal of care Hemodynamic instability due to active hemorrhage Acute coronary syndrome Indication for immediate surgery Received CPR within 24 hours of enrollment Pregnancy.

结局指标

主要结局

Incidence of global fluid overload by measuring VExLUS score

时间窗: 0-12hrs | 24-36hrs | 48-72hrs | Discharge time

次要结局

  • To asses correlation between VexLUS score and cumulative fluid balance(0-12hrs)
  • To asses correlation between VexLUS score and acute kidney injury(0-12hrs)
  • To asses correlation between VexLUS score and ICU length stay(0-12hrs)
  • To asses correlation between VexLUS score and congestive respiratory failure(not attributed to other causes)(0-12hrs)
  • Proportion of the need for diuretic use or Renal Replacement therapy to correct fluid overload(0-12hrs)
  • To predict 28 day mortality on VexLUS score(0-12hrs)

研究者

发起方
All India Institute of Medical Sciences Patna
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr D Prithvi

AIIMS Patna

研究点 (1)

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