Nebulized Epinephrine Versus Nebulized Salbutamol in Bronchiolitis Among Children Aged 1month-24months
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Length of stay
研究概览
简要总结
Acute bronchiolitis, mostly secondary to infection due to Respiratory syncytial virus (RSV) is very common in infants under two years old. It is usually benign. However, the dyspnea it causes is a big concern for parents and this disease can take a severe form on certain particular ground thus constituting a frequent reason for hospitalization in pediatrics. Nebulized epinephrine showed more efficacy than nebulized salbutamol.
详细描述
The objective of this study is to determine if nebulized epinephrine is more efficacious than nebulized salbutamol in all hospitalized children (1 month to 24 months) in treatment of bronchiolitis. A randomized clinical trial which recruits children admitted to the pediatrics department with diagnosis of bronchiolitis. Children aged 1 month to 2 years will be included in the study.
Children who meet the inclusion criteria will be alternately distributed in two groups:
Group 1:
Will receive salbutamol (2 units/kg) with 3 ml normal saline by nebulizer.
Group 2:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 1 Month 至 24 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children diagnosed with acute bronchiolitis.
排除标准
- •Children with congenital heart disease or
- •chronic lung diseases
研究组 & 干预措施
Salbutamol
Patients will receive salbutamol (2 units/kg) with 3 ml normal saline by nebulizer.
干预措施: Salbutamol (Drug)
Epinephrine
Patients will receive epinephrine (0.5 mg/dose) with 3 ml normal saline by nebulizer.
干预措施: Epinephrine (Drug)
结局指标
主要结局
Length of stay
时间窗: 5 days
Patients hospitalization duration will be recorded
次要结局
- Respiratory distress scoring(5 days)
研究者
Mariam Rajab
Clinical professor
Makassed General Hospital