Efficacy of aspirin desensitization in nasal polyposis
Not Applicable
- Conditions
- nasal polyp.Polyp of nasal cavity
- Registration Number
- IRCT2016070728821N1
- Lead Sponsor
- Vice chancellor for research, Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
chronic rhinosinusitis (CRS) with nasal polyposis patients more than 18 years old that is admitted in allergy clinic. CRS diagnose criteria:(1) 2 or more of symptoms: nasal congestion; pain or pressure of face; post or anterior discharge; loss of smell. (2) Symptoms should stay more than 12 week. CRS with nasal polyposis diagnose will confirm by CT SCAN or endoscopy of sinus.
Exclusion criteria: Forced expiratory volume at first second less than 70% in spirometry; gastrointestinal bleeding; pregnancy or breast feeding; Anaphylaxy to Nonsteroidal anti inflammatory drugs (NSAID); Myocardial infarction or stroke in last 6 month and sever liver or kidney disease.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quality of life. Timepoint: Before and one month after intervention. Method of measurement: Questiner.;Respiratory function. Timepoint: Before and one month after intervention. Method of measurement: Spirometry.
- Secondary Outcome Measures
Name Time Method Interleukin 4. Timepoint: Before and onemonth after intervention. Method of measurement: Quantitative pg/ml.;Interleukin 5. Timepoint: Before and onemonth after intervention. Method of measurement: Quantitative pg/ml.