NCT05093400已完成不适用
Oropharynx (OPX) Salivary Biomarker Study: Microbiome, Virome, and Metabolomics
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Oncologic strains in HPV DNA salivary samples
研究概览
简要总结
The goal of this study is to analyze certain biomarkers to look at the relationship between HPV in the saliva, stage at presentation, and a potential self-test compared to saliva of non-cancerous participants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Oropharynx or Oral Cavity Squamous Cell Carcinoma Patients: collected under the OPX Biomarker Protocol (IRB: 19-006036).
- •Normal Controls:
- •Age ≥ 18 years;
- •Able to provide informed written consent documenting permission to give saliva sample for research testing.;
- •Ability to complete questionnaire(s) by themselves or with assistance.
排除标准
- •Oropharynx or Oral Cavity Squamous Cell Carcinoma Patients: collected under the OPX Biomarker Protocol (IRB: 19-006036).
- •Normal Controls:
- •Any personal history of head or neck cancer including head or neck skin cancer.
- •Other active malignancy ≤ 5 years prior to registration.
- •EXCEPTIONS: Non-melanotic skin cancer, non-metastatic prostate cancer.
- •NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer.
- •Dry mouth (xerostomia) caused by any chronic (>30 days) condition (known or unknown) or medication.
- •Recent (within 30 days) or active upper aerodigestive tract or anogenital infections.
结局指标
主要结局
Oncologic strains in HPV DNA salivary samples
时间窗: 2 years
Number of patients to have oncologic strains of HPV DNA in salivary samples
次要结局
未报告次要终点
研究者
Kathryn (Katie) M. Van Abel
Principal Investigator
Mayo Clinic
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Oropharynx (OPX) Biomarker TrialMetastatic Oropharyngeal Squamous Cell CarcinomaOropharyngeal Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell CarcinomaHead and Neck CarcinomaHead and Neck NeoplasmSalivary Gland NeoplasmsThyroid Gland NeoplasmNCT06356272Mayo Clinic560
终止
不适用
Monitoring of Oral Human Papillomavirus Infection (HPV) in HPV-positive Oropharyngeal Squamous Cell Carcinoma (OPSCC)Carcinoma, Squamous CellHead and Neck NeoplasmsOropharyngeal NeoplasmsNCT02045186UNC Lineberger Comprehensive Cancer Center1
已完成
不适用
Molecular Signatures of HPV+ ORL Cancers (OROPAP)Human Papillomavirus-Related CarcinomaOropharyngeal CancerNCT04189003Assistance Publique - Hôpitaux de Paris66
已完成
不适用
Biomarker research on the association between the effect and the HPV infection on the multimodal therapy for oropharyngeal squamous cell carcinomaOropharyngeal squamous cell carcinomaJPRN-UMIN000021572The study group of basic research of the head and neck80
进行中（未招募）
不适用
Circulating Biomarkers in Oropharyngeal CancersOropharynx Squamous Cell CarcinomaOropharynx CancerTonsillar CancerBase of the Tongue CarcinomaNCT05904327Region Örebro County130