Evaluation the effect o f Remifentanil on Succinylcholine-indused biochemical changes during anesthesia
Phase 2
- Conditions
- Complication of muscle relaxant drugs (succinylcholine), not elsewhere classified.Other adverse effects, not elsewhere classified
- Registration Number
- IRCT138810141766N3
- Lead Sponsor
- Kurdistan University of Medical Sciences, Research Department
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Scheduled for elective surgery of lower abdomen (such as inguinal hernia, hydrocele and ...), signing informed consent, ASA class of 1 or 2. Exclusion criteria: addiction (opioides, alcohol, or psychological drugs), history of allergic reaction to study drugs, cholinesterase deficiency, hypertension, neuromuscular disease, pregnancy, and using drugs that interact with neuromuscular function.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum potassium level changes. Timepoint: befor induction of anesthesia and 5 minutes after injection of succinylcholine. Method of measurement: Laboratory.;Serum creatine phosphokinase level (CPK) changes. Timepoint: before induction of anesthesia and 24 hours after that. Method of measurement: Laboratory.
- Secondary Outcome Measures
Name Time Method Blood pressure changes. Timepoint: Before induction of anesthesia, after induction of anesthesia and after tracheal intubation. Method of measurement: Clinically (automated pressure gauge).;Heart rate changes. Timepoint: before induction of anesthesia, after induction of anesthesia and after tracheal intubation. Method of measurement: Clinically (by automated monitoring).;Postoperative myalgia. Timepoint: In 5 times, 2, 6, 24, 48 and 72 hours after operation. Method of measurement: By a 4-point scale questionnaire.;Duration of fasciculation. Timepoint: after injection of succinylcholine. Method of measurement: Chronometer.