Coordination Training With Complete Body Video Games in Children and Adults With Degenerative Ataxias
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Spinocerebellar Ataxia
- Sponsor
- University Hospital Tuebingen
- Enrollment
- 10
- Primary Endpoint
- Fast alternating hand movements
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Exergame training might offer a novel treatment approach even in largely nonambulatory subjects with multisystemic degenerative spinocerebellar ataxia.
Detailed Description
Effective treatments for patients with degenerative spinocerebellar ataxia are scarce. It has recently been shown that intensive coordinative training based on either physiotherapy or exergames (= whole-body controlled videogames; might improve degenerative ataxia, but its effectiveness is still disputed. This situation is even more complicated for degenerative ataxia subjects in advanced disease stages and with high multisystemic disease load. Here, underlying neurodegeneration has progressed to many irreversible states and includes many additional extra-cerebellar systems, making functional plasticity and therapeutic success much less likely. Moreover, intervention outcome assessment in subjects unable to walk freely is more delicate. Correspondingly, nonambulatory ataxia subjects in advanced disease stages are currently often excluded from treatment trials, thus leaving them without prospects of access to novel treatments. The investigators here hypothesized that exergame training might offer a novel treatment approach even in largely nonambulatory subjects with multisystemic degenerative spinocerebellar ataxia. Using a rater-blinded, intraindividual control study design, the investigators show that an individualized exergame training strategy, tailored to individuals' disease stage, improves postural control and ataxia-specific control functions even in advanced disease.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Advanced spinocerebellar disease
- •Advanced impairments in gait and stance, defined as Scale for Assessment and Rating of Ataxia (SARA) subscore gait ≥3 and stance ≥3, but still able to sit without support \>10 seconds, as defined by SARA subscore sitting \<3
- •Age between 5 and 30 years
Exclusion Criteria
- •Any signs of inflammatory, vascular, malformation, or tumor cerebrospinal (CNS) disease
- •Visual loss, hearing disturbances, mental retardation and predominant non-ataxia movement disorders (e.g. predominant spasticity, chorea, parkinsonism)
Outcomes
Primary Outcomes
Fast alternating hand movements
Time Frame: Week 13
Item 7 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Gait
Time Frame: Week 13
Item 1 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Stance
Time Frame: Week 13
Item 2 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Sitting
Time Frame: Week 13
Item 3 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Speech disturbance
Time Frame: Week 13
Item 4 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Finger chase
Time Frame: Week 13
Item 5 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Nose-finger Test
Time Frame: Week 13
Item 6 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Heel-shin slide
Time Frame: Week 13
Item 8 of the Scale for the Assessment and Rating of Ataxia (SARA) score; total score made up of item 1 - 8
Secondary Outcomes
- Goal attainment Score(Week 13)
- Quantitative movement analysis(Week 13)