Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

Completed

• Conditions: Obesity, Metabolically Benign
• Interventions: Other: MetS+; Other: MetS-

• Registration Number: NCT03354676
• Lead Sponsor: Alexandru Florin Rogobete

Brief Summary

Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Detailed Description

The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Study Timeline

• Study Start: 2016-03-11
• Primary Completion: 2017-08-11
• Study Completion: 2017-09-10
• Study First Submitted: 2017-09-12
• Status Verified: 2017-11
• Study First Submitted QC: 2017-11-26
• Last Update Submitted: 2017-11-26
• Study First Posted: 2017-11-28
• Last Update Posted: 2017-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

• obese children (BMI> 95th percentile)

Exclusion Criteria

• obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MetS+	MetS+	Obese group with metabolic syndrome/Data processing from Patient Medical Files
MetS-	MetS-	Obese group without metabolic syndrome/Data processing from Patient Medical Files

Primary Outcome Measures

Name	Time	Method
Defining obesity in the pediatric population	Weight and height were measured on day 1 of admission. Obesity was defined as a BMI > the 95th percentile.	Measuring weight in kilograms and height in meters in order to calculate BMI and represent it on the percentile graph.
Leptin changes in the obese children with metabolic syndrome	Leptin levels were measured on day 1 of admission. Normal range was considered < 24ng/ml.	Evaluating leptin in the obese group with metabolic syndrome
Assessing cardiovascular risk in the obese children with metabolic syndrome	hsCRP levels were measured on day 1 of admittance in children aged between 4 and 18 years. Normal levels were considered between 0.1-2.8 mg/l	Evaluating hsCRP in the obese group with metabolic syndrome
Adiponectin changes in the obese children with metabolic syndrome	Adiponectin levels were measured on day 1 of admittance in children aged between 4 and18 years. Levels 4-26 mcg/ml were defined as normal values.	Evaluating adiponectin in the obese group with metabolic syndrome