europhysiological and molecular biological investigations into sensory processing of chronic pruritus with cutaneous and non-cutaneous causes in the cowhage model (Pruri-Cow)
- Conditions
- L29.9Pruritus, unspecified
- Registration Number
- DRKS00005226
- Lead Sponsor
- IZKF der medizinischen Fakultät der Universität Münster
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 160
chronic pruritus in
atopic dermatitis (AD; sub-acute, chronic)
OR brachioradial pruritus (BRP)
OR prurigo nodularis (PN)
controls (no atopic disposition, no dermatoses)
1. only control subjects: History taking on atopic disposition (us-ing Erlangener atopy criteria), presence of pruritus
2. skin lesions in the area to be investigated (e.g. erosions, infections, acute exacerbation, cutaneous infections in atopic dermatitis),
3. neurological and psychiatric diseases in the patient history or currently suffering from the disease
4. skin type > III (mediterranean, dark and black skin type),
5. allergy to substances used /ingredients of the cream,
6. disorders preventing participation in the investigation,
7. intake of a drug, which influences the pruritus perception within the 2 weeks before examination
8. use of urea, polidocanol, menthol, capsaicin, topical steroids, topical keratolytics, exfoliators, self-tanning, topical or systemic antihistamines, naltrexon, anticonvulsants, sedatives within the 2 weeks before examination
9. systemic steroids, UV-therapy within the 4 weeks before examination
10. topical or systemic immunomodulators, antidepressants, anti-migraine medications within the 2 months before examination
11. NSAIDs and other analgesics 7 days before examination,
12. drug consumption, medication abuse,
13. cosmetic and skin care products in the area to be investigated on the day of examination,
14. participation in another investi-gation within the past 4 weeks
15. pregnancy, nursing mother
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method difference of cowhage-induced itch intensity on VAS in CP entities in comparison to controls
- Secondary Outcome Measures
Name Time Method