Examining the efficacy of brain stimulation for a neuropsychiatric disorder called OCD
- Conditions
- Health Condition 1: null- Patients with Obsessive Compulsive Disorder
- Registration Number
- CTRI/2018/06/014360
- Lead Sponsor
- ational Institute of Mental Health And Neurosciences NIMHANS Bangalore
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria:
1.Diagnosis of OCD as per DSM-V criteria (American Psychiatric Association, 2013)
2.Age Range: 18 â?? 50 Years
3.Either Sex
4.Right-handedness
5.Stable psychotropic medications atleast for 12 weeks and not on cognitive behavioral therapy presently
6. Persistent symptoms despite adequate SSRI treatment (OCD symptom severity according to Yale Brown Obsessive Compulsive Scale score of atleast 16)
Healthy controls: Right handed;age,sex and education matched
1.Comorbid psychosis, bipolar disorder, substance dependence (including nicotine dependence) features suggestive of psychiatric emergency (for example: suicidal risk, catatonia, prolonged nutritional deprivation, aggression or excitement)
2.Any contraindication to HD-tDCS procedure-(i) metal in the head,(ii) implanted brain medical devices,(iii)local lesion or injury in the scalp / head
3.Co-morbid neurological/medical disease that can affect the brain structure/function
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional MRI (fMRI)- Resting fMRI and with cognitive activation task(Symptom provocation paradigm followed by Stop-signal task)Timepoint: Baseline and after 10 days of HD tDCS sessions
- Secondary Outcome Measures
Name Time Method Magnetic resonance Spectroscopy â?? MRS for NAA and glutamate in-vivo signals at pre-SMA <br/ ><br>Error Related Negativity (ERN) <br/ ><br>Clinical assessments - illness severity ratingsTimepoint: Baseline and after 10 days of HD tDCS sessions