Effects of Non-invasive Direct Current Technique in Schizophrenia
- Conditions
- Health Condition 1: null- Schizophrenia
- Registration Number
- CTRI/2016/02/006612
- Lead Sponsor
- ational Institute of Mental Health and NeuroSciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 42
1) Diagnosis of schizophrenia/schizophreniform disorder as per DSM-V criteria (Diagnostic and Statistical Manual for Mental Disorders, American Psychiatric Association, 2013);
2) Clinically Significant Auditory Verbal Hallucinations as defined by the Auditory Hallucination Rating Scale (Haddock et al 1999) items on frequency, duration and disruption each having a score >= 2;
3) Stable antipsychotic medication dose atleast for the past 4 weeks with no change in auditory hallucination severity;
4) Age: 18 â?? 45 years;
5) Both sexes;
6) Right Handedness and
7) Written informed consent.
1) Features suggestive of psychiatric emergency (suicidal risk, aggression, excitement, catatonia, prolonged nutritional deprivation or any other status requiring intensive clinical care);
2) Any contraindication to tDCS procedure â?? (i) metal in the head, (ii) implanted brain medical devices, (iii) local lesion or injury in the scalp / head;
3) Any co-morbid psychiatric diagnosis;
4) Left Handedness.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Improvement in auditory verbal halluciantion <br/ ><br>2. Changes in hemodynamic response, fronto-temporo-parietal network connectivity <br/ ><br>3. Profile of auditory processing efficiency <br/ ><br>4. Impact of neuroplasticity gene polymorphismTimepoint: Assessments will be done twice, before starting tDCS and after completion of tDCS 5 days course
- Secondary Outcome Measures
Name Time Method CognitionTimepoint: Assessments will be done twice, before starting tDCS and after completion of tDCS 5 days course