eurobiological correlates and mechanisms of the augmentation of psychotherapy with endurance exercise in mild to moderate depressio

Not Applicable

• Conditions: F32.0; F32.1; F33.0; F33.1; Mild depressive episode; Moderate depressive episode; Recurrent depressive disorder, current episode mild; Recurrent depressive disorder, current episode moderate

• Registration Number: DRKS00008869
• Lead Sponsor: Department Sport- und Gesundheitswissenschaften, Sozial- und Präventivmedizin, Universität Potsdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-28
• Study Completion: 2019-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

The study is conducted with 18- to 65- years old, as physical healthy diagnosed ambulant psychotherapy patients with the main diagnosis of a mild to moderate depressive episode diagnosed according to ICD-10 (F32.0, F32.1), which can also occur in the context of a recurrent depressive disorder (F33.0, F33.1). The presence of a major depressive episode is assured by creating structured clinical interview I for DSM - IV (SCID I) ; Axis I: mental disorders, depression section.
The healthy control group (18-65 years old).
Subjects of the healthy control group are 18-65 years old and have no major depressive disorder.

Exclusion Criteria

Following exclusion criteria are applied: current severe depressive episode with and without psychotic symptoms (F32.2, F32.3, F33.2 or F33.3), current borderline or dissocial personality disorder, acute suicide risk, current or lifetime schizophrenia spectrum disorder, delusional disorders (F2x.x), bipolar affective disorder (F31.x), current dependence (alcohol, heroin, amphetamine, cocaine), minimum period of rest 12 month, current severe neurological diseases and illnesses of central nervous system, severe chronic obstructive pulmonary disease (COPD), coronary heart disease, cardiac insufficiency, anaemia, body mass index > 35 or < 18, language problems, non-correctable hearing and visual impairments, MRI unsuitability, current use of benzodiazepines or beta blockers within the last 7 days, tricyclic antidepressants with a dose of > 50mg per day, neuroleptics with a dose of > 30% of the maximum daily dose, regular endurance training (more than two times per week for 45min).

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of depressive symptoms measured via self rating (Beck Depression Inventory, BDI) and external rating (Hamilton Rating Scale for Depression, HAM-D) from baseline to follow-up (t1: baseline, t2: after exercise therapy respectively waiting period, t3: after psychotherapy, t4: follow up) .