eurobiological Correlates and Predictors of Psychotherapeutic Processes in Patients with OCD
Not Applicable
- Conditions
- F42Obsessive-compulsive disorder
- Registration Number
- DRKS00000290
- Lead Sponsor
- Klinik für Psychiatrie und Psychotherapie Universitätsklinikum Schleswig-Holstein Campus Lübeck
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
OCD diagnosis according to DSM-IV (SCID)
- Y-BOCS total score of 16 or more
- Illness duration of at least one year
- Absence of psychoactive medication (at least 4 weeks wash-out)
- Right handedness (according to EHI)
Exclusion Criteria
- Concurrent major depression
- Acute Suicidality
- Substance abuse or dependence (present and history of)
- History of major head trauma
- Major neurological and somatic illnesses
- Pregnancy and lactation
- Absence of contraception in fertile women
- Concurrent participation in other clinical trials, including 30 days before enrollment
- Generally accepted exclusion criteria for participation in MRI research (http://www.ismrm.org)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -Symptom Reduction (Yale-Brown-Obsessive-Compulsive Scale; Clinical Global Impression)<br>- Cognitive Performance (Neuropsychological Test Battery) at T0 and T2<br>- Concentration of neurometabolites in the brain tissue (Proton Magnetic Resonance Spectroscopy; 1H-MRS) at T0 and T2<br>- Fractional Anisotropy of white matter of the brain (Diffusion Tensor Imaging; T0 and T2)<br>- BOLD-Signal as measured with functional Magnetic Resonance Imaging (fMRI) during cognitive activation and rest
- Secondary Outcome Measures
Name Time Method Change of depressive symptoms (Hamilton Depression Rating Scale and Beck Depression Inventory, at timepoints T0 and T2)