NCT00181116
Completed
Phase 4
Efficacy of Levetiracetam for Language Dysfunction Associated With Benign Epilepsy With Centrotemporal Spikes
ConditionsEpilepsy
DrugsLevetiracetam
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Epilepsy
- Sponsor
- Johns Hopkins University
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- Language improvement
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
This study is designed to test if the language problems commonly seen in children with benign rolandic epilepsy would improve by switching anticonvulsants to levetiracetam.
Detailed Description
This is a 6 month study in which children on another anticonvulsant would have EEG, language testing, and a clinic visit at baseline. They would then be rapidly transitioned off of their current anticonvulsant and onto levetiracetam (Keppra). Repeat EEG and language testing would be done after 6 months to evaluate for improvement.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Ages 6-12
- •Benign rolandic epilepsy
- •Language difficulties as reported by parents or teachers
- •On another anticonvulsant other than levetiracetam
Exclusion Criteria
- •Prior use of levetiracetam
- •On 2 or more anticonvulsants
- •Language problems prior to epilepsy
- •Another seizure disorder
- •Status epilepticus within the past 6 months
- •Significant psychiatric disease
- •Progressive neurologic disease
Outcomes
Primary Outcomes
Language improvement
Secondary Outcomes
- Seizure control
Study Sites (1)
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