Influence of Muscle Typology and Training Frequency on Chronic Strength Training Adaptations
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Muscle Fiber Type
- Sponsor
- University Ghent
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Change from baseline isometric muscle strength at 9 weeks
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.
Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Fast or slow muscle typology
- •18 - 45 years old
- •no strength training experience
Exclusion Criteria
- •Vegan/vegeterian diet
- •Supplement intake
- •chronic diseases
- •Hypertension,
- •Medication use
- •Coagulation disorder, infectious diseases
Outcomes
Primary Outcomes
Change from baseline isometric muscle strength at 9 weeks
Time Frame: Pre and post 9 weeks training period
Upper legs and upper arms - Biodex
Change from baseline dynamic muscle strength at 6 weeks
Time Frame: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline muscle volume at 9 weeks
Time Frame: Pre and post the 9 weeks training period
Muscle volume of the legs and the upper arms - MRI
Change from baseline dynamic muscle strength at 3 weeks
Time Frame: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change from baseline dynamic muscle strength at 9 weeks
Time Frame: Pre, mid and post 9 weeks training period
Upper legs and upper arms - strength training devices
Change in muscle fiber type specific hypertrophy at 9 weeks
Time Frame: Pre and post 9 weeks training period
Legs - Biopsy (vastus lateralis)
Secondary Outcomes
- Change of baseline antropometry at 9 weeks(Pre and post 9 weeks training period)
- Change of baseline skeletal muscle protein content at 9 weeks(Pre and post 9 weeks training period)
- Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks(Pre and post 9 weeks training period)
- Change of baseline histochemistry at 9 weeks(Pre and post 9 weeks training period)
- Change from basline fatigue feeling over 9 weeks training period(Assessed every training during the 9 weeks training period)