Effects of salsalate on glucose metabolism
- Conditions
- Diabetes Mellitus.Non-insulin-dependent diabetes mellitus
- Registration Number
- IRCT138709011465N1
- Lead Sponsor
- Isfahan Endocrine and Metabolism Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 180
HbA1c>=5% and BS<250 and (FBS>=100mg/dl or BS>=140mg/dl in OGTT) Exclusion criteria: Type 1 DM or past history of DKA, pregnancy/lactation, surgery within 1 month before the trial, known diagnosed malignancy, confirmed peptic ulcer or GI bleeding, diagnosed heart failure (function class 3 or 4), clinical ACS, CVA, TIA, revascularization within 6 month prior to study, uncontrolled hypertension (systolic BP>150 mmHg or diastolic BP>100 mmHg with full dose of 3 drugs) , history of drug abuse or alcohol consumption, history of active hepatitis , psychological disorders , previous allergy to aspirin or NSAIDS , continuous use of NSAIDS , Warfarin, Clopidogrel, Corticosteroid, Macroalbuminuria, chronic tinnitus, Hb<12 mg/dl in men and Hb<10 in women , platelets<100000, Triglyceride>500 mg/dl , serum creatinine more than 1.4 in women and more than 1.5 in men or GFR<60.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fasting blood glucose. Timepoint: weeks ( 0, 4, 8, 12). Method of measurement: Enzymatic.
- Secondary Outcome Measures
Name Time Method Insulin resistance. Timepoint: weeks ( 0 , 4 , 8 , 12). Method of measurement: (plasma insulin)(plasma glucose)/22.5=HOMA-IR.