External cooling as a stabilizing cardiovascular countermeasure in hypergravity
- Conditions
- orthostatic intolerance
- Registration Number
- DRKS00015433
- Lead Sponsor
- DLR - Institut für Luft- und Raumfahrtmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 18
• Healthy male participants aged between 18 and 50 years old with a Body Mass Index (BMI) of 18-26 kg/m2 and a height of 170-210 cm
• Successful completion of screening examination
• physically fit (VO2max at least 35 ml/kg/min) and experience with +Gz (if possible)
• Ability to comprehend and consent to the risks associated with the study to provide informed consent
• In the position to participate in the complete study.
• Drug or alcohol abuse (regular consumption of 20-30 g alcohol/day)
• Regular smokers
• Current muscle or joint disease
• Allergies to ultrasound gel or its ingredients
• Diabetes mellitus
• Herniated disc
• Use of psychotropic drugs and any other drugs that may affect the study experiments
• Heart disease or a cardiac pacemaker
• Abnormal blood pressure (above 140/90 mmHg or below 90/60 mmHg)
• Severe orthostatic intolerance or impaired neurovestibular function
• Kidney disease (deviations from normal values of creatinine in plasma; Creatinine normal value < 1.20 mg/dL)
• Thyroid dysfunction (deviations from normal values for TSH in plasma; normal values TSH 0,27 – 4,20 mU/l) (a laboratory examination carried out only in case of suspicion of dysfunction)
• Anemia (Hb lower the normal value; standard value Hb men: from 13.5 to 17.5 g/dL)
• History of epileptic seizures
• Chronic back pain
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in blood pressure at the end of the centrifuge protocol is lower when subjects are cooled compared with the uncooled subjects.
- Secondary Outcome Measures
Name Time Method