Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
- Conditions
- Squamous Non Small Cell Lung CancerNon Small Cell Lung CancerNonsquamous Non Small Cell Lung CancerLung Cancer
- Interventions
- Registration Number
- NCT04736173
- Lead Sponsor
- Arcus Biosciences, Inc.
- Brief Summary
This is a phase 2 study to evaluate zimberelimab (AB122) combined with domvanalimab (AB154) in front-line, PD-L1-high, locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 169
-
Histologically confirmed, treatment naïve, locally advanced or metastatic (stage IIIB IV per AJCC version 8), squamous or non-squamous NSCLC with documented high PD L1 expression (TC ≥ 50%) as determined by the VENTANA SP263 IHC assay, as assessed by central laboratories).
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Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
-
Must have at least 1 measurable lesion per RECIST v1.1
-
Adequate organ and marrow function
-
If a participant has brain or meningeal metastases, the participant must meet the following criteria:
- Have no evidence of progression by neurologic symptoms or signs for at least 4 weeks prior to the first dose.
- Participants with previously treated brain metastases may participate provided they have stable central nervous system (CNS) disease for at least 4 weeks prior to enrollment. Stable CNS disease is defined as resolution of all neurologic symptoms to baseline, having no evidence of new or enlarging brain metastases, and not requiring use of corticosteroids for CNS disease for at least 14 days prior to the start of study treatment. Participants who have had brain metastases resected or have received whole brain radiotherapy ending at least 4 weeks (or stereotactic radiotherapy ending at least 2 weeks) prior to initiation of study treatment are permitted.
- Carcinomatous meningitis is excluded regardless of clinical stability.
Key
- Presence of any tumor genomic aberration or driver mutation for which a targeted therapy is approved by local health authority and available
- Use of any live vaccines against infectious diseases within 28 days of first dose
- Any active autoimmune disease or a documented history of autoimmune disease or syndrome that required systemic treatment in the past 2 years (ie, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs), except for vitiligo or resolved childhood asthma/atopy.
- Prior malignancy active within the previous 2 years except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix, breast, or prostate cancer
- Prior treatment with any anti-PD-1, anti-PD-L1 or any other antibody targeting an immune checkpoint.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm C - Study Part 1 (Domvanalimab + Zimberelimab Combination Therapy) Domvanalimab Participants will receive zimberelimab in combination with AB154 by IV infusion. Arm D - Study Part 2 (Domvanalimab + Zimberelimab Combination Therapy) Domvanalimab Participants will receive domvanalimab in combination with zimberelimab by IV infusion. Arm A - Study Part 1 (Platinum-based Chemotherapy) Carboplatin Participants will receive carboplatin, pemetrexed, and paclitaxel by intravenous (IV) infusion. Arm C - Study Part 1 (Domvanalimab + Zimberelimab Combination Therapy) Zimberelimab Participants will receive zimberelimab in combination with AB154 by IV infusion. Arm B - Study Part 1 (Zimberelimab Monotherapy) Zimberelimab Participants will receive zimberelimab monotherapy by IV infusion. Arm A - Study Part 1 (Platinum-based Chemotherapy) Paclitaxel Participants will receive carboplatin, pemetrexed, and paclitaxel by intravenous (IV) infusion. Arm A - Study Part 1 (Platinum-based Chemotherapy) Pemetrexed Participants will receive carboplatin, pemetrexed, and paclitaxel by intravenous (IV) infusion. Arm D - Study Part 2 (Domvanalimab + Zimberelimab Combination Therapy) Zimberelimab Participants will receive domvanalimab in combination with zimberelimab by IV infusion. Arm E - Study Part 2 (Pembrolizumab) Pembrolizumab Participants will receive pembrolizumab by IV infusion.
- Primary Outcome Measures
Name Time Method Progression-free Survival (PFS) From randomization until death from any cause (up to 7 years)
- Secondary Outcome Measures
Name Time Method Number of Participants With treatment-emergent adverse events From randomization until death from any cause (up to 7 years) Confirmed Overall Response Rate (ORR) From randomization until death from any cause (up to 7 years) Overall Survival (OS) From randomization until death from any cause (up to 7 years)
Trial Locations
- Locations (91)
Hope and Healing Cancer Service
🇺🇸Hinsdale, Illinois, United States
General hospital of Athens, chest diseases Sotiria
🇬🇷Athens, Greece
University General Hospital "Attikon"
🇬🇷Chaidari, Greece
General Oncology Hospital of Kifissia " Agioi Anargyroi"
🇬🇷Kifissia, Greece
General Hospital of Patra Agios Andreas
🇬🇷Patras, Greece
Hong Kong Integrated Oncology Centre
🇭🇰Hong Kong, Hong Kong
Hong Kong United Oncology Centre
🇭🇰Hong Kong, Hong Kong
Humanity and Health Clinical Trial Centre
🇭🇰Hong Kong, Hong Kong
Princess Margaret Hospital
🇭🇰Hong Kong, Hong Kong
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
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