Influence of carbon dioxide on dynamic cerebral autoregulation during simulated microgravity
Not Applicable
- Conditions
- Healthy adult volunteers. e.g. astronauts, or exposure to carbon dioxide during head down tilt, etc.
- Registration Number
- JPRN-UMIN000017157
- Lead Sponsor
- Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine
- Brief Summary
Exposure to 3%CO2 during 10 degree HDT increased gain LF, suggesting that dynamic cerebral autoregulation is impaired by a combination of hypercapnia and cephalad fluid shift.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
Not satisfy selection criteria noted above
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gain, coherence and phase between arterial blood pressure and cerebral blood flow velocity during 10-min exposure to CO2 with head-down tilt
- Secondary Outcome Measures
Name Time Method cerebral blood flow velocity, pulsatility index, blood pressure variability, cerebral blood flow velocity variability, respiratory indexes, intracranial pressure, NIRS, baroreflex function, HRV