The Comparison of Dexmedetomidine and Midazolam for the Sleep of Mechanical Ventilated Intensive Care Unit Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 5
- Locations
- 1
- Primary Endpoint
- The differences of sleep stage, sleep efficiency, arousal index and delirium between dexmedetomidine group and midazolam group
Study Overview
Brief Summary
The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography in critically ill patients. And the investigators also compare the incidence of delirium between the two groups.
Detailed Description
Sleep is very important for cognitive and immune function. However, patients in intensive care unit (ICU) have a very poor sleep.
Almost all ventilated patients in intensive care unit (ICU) take a sedative drug. In Korea, most commonly used sedative drugs are dexmedetomidine and midazolam.
The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography. And the investigators also compare the incidence of delirium between the two groups.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •sedation patients with dexmedetomidine or midazolam
- •over 18 years old
Exclusion Criteria
- •Neurologic disease (stroke, seizure, dementia, hypoxic brain damage)
- •Brain infection
- •Alcoholics
- •Major Depression Disorder, Schizophrenia, Anxiety disorder
- •Hearing loss
Outcomes
Primary Outcomes
The differences of sleep stage, sleep efficiency, arousal index and delirium between dexmedetomidine group and midazolam group
Time Frame: during ICU stay
Secondary Outcomes
No secondary outcomes reported