Incidence of post COVID-19 interstitial lung disease and impacts on lung function and quality of life

• Conditions: Post-COVID-19 ILD; Post-COVID-19 interstitial lung disease

• Registration Number: TCTR20220419013
• Lead Sponsor: Routine to Research (R2R) Project, Faculty of Medicine Siriraj Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-19
• Study Completion: 2023-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: nknown
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

1. Age more than or equal to 18 years
2. Confirm diagnosis of COVID-19 infection by RT-PCR of respiratory specimens
3. Confirm diagnosis of pneumonia
4. Hospitalized in Siriraj Hospital (general wards and critical care units)
5. Persistent respiratory symptom after 6 months of date of symptom with abnormal chest X-ray

Exclusion Criteria

1. Pre-existing chronic lung diseases, including interstitial lung disease and bronchiectasis
2. Pregnant woman
3. No persistent respiratory symptom after 6 months of date of symptom
4. Normal chest X-ray after 6 months of date of symptom
5. Unable to perform high resolution computed tomography
6. Unable to perform pulmonary function tests
7. Presence of contraindication for pulmonary function tests
8. Deny to enroll

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of post-COVID-19 interstitial lung disease 6 months after date of symptoms Medical record and HRCT official report

Secondary Outcome Measures

Name	Time	Method
Pulmonary function tests and associated factor of severity of impairment 6 months after date of symptoms Official report of pulmonary function tests,Quality of life and associated factor of severity of impairment 6 months after date of symptoms Questionaire (EQ-5D-5L and SGRQ),Changes of HRCT abnormalities 6 months after date of symptoms HRCT official report and radiologist consultation