Evaluation of the Luteolytic Effect of a Gonadotropin Releasing Hormone (GnRH) Agonist After the Administration of Human Chorionic Gonadotropin (hCG) in the Initial Follicular Phase a Its Influence on the Prognosis of in Vitro Fertilization Treatment
试验速览
- 阶段
- 3 期
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Frequency of functional rescue of corpus luteum
研究概览
简要总结
This study was designed to evaluate the ability of gonadotropin releasing hormone (GnRh) agonist to prevent the rise of progesterone during controlled ovarian stimulation for in vitro fertilization (IVF) after the administration of human Chorionic Gonadotropin (hCG) on the first day of menses.
详细描述
The aim of this study is to evaluate the efficacy of a GnRH agonist in preventing the functional rescue of corpus luteum in women submitted to controlled ovarian stimulation with administration of hCG on the first day of menses and to evaluate its effect on pregnancy rate and ovarian steroidogenesis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •age >21 and < 38 years old
- •polycystic ovarian syndrome
- •risk for ovarian hyperstimulation syndrome
排除标准
- •recurrent abortion
- •endometriosis
- •more than 3 IVF failures
- •use of oral contraceptive pills in the preceding 3 months
- •low response to gonadotropins
研究组 & 干预措施
GnRH agonist
3,6 mg of goserelin acetate (GnRH agonist) will be administered on the 21st day of the menstrual cycle previous to ovarian stimulation. 250 mg of hCG will be administered on the first day of menses and a starting dose of 150 IU of FSH will be started 2 days later as a part of a long ovarian stimulation protocol. Ovulation will be triggered with a 250 mg of hCG when at least 2 follicles attain 18mm and to accommodate oocyte retrieval within 36 hours.
干预措施: GnRH agonist (Drug)
Control
250 mg of hCG will be administered on the first day of menses and a starting dose of 150 IU of FSH will be started 2 days later as a part of a long ovarian stimulation protocol. Ovulation will be triggered with a 250 mg of hCG when at least 2 follicles attain 18mm and to accommodate oocyte retrieval within 36 hours.
干预措施: Control (Drug)
结局指标
主要结局
Frequency of functional rescue of corpus luteum
时间窗: 6 months
次要结局
- Pregnancy rate(6 months)
- Levels of serum steroids(6 months)
- Levels of serum gonadotropins(6 months)