Evaluation of the Luteolytic Effect of a Gonadotropin Releasing Hormone (GnRH) Agonist After the Administration of Human Chorionic Gonadotropin (hCG) in the Initial Follicular Phase a Its Influence on the Prognosis of in Vitro Fertilization Treatment
Overview
- Phase
- Phase 3
- Intervention
- GnRH agonist
- Conditions
- Infertility
- Sponsor
- University of Sao Paulo
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Frequency of functional rescue of corpus luteum
- Last Updated
- 16 years ago
Overview
Brief Summary
This study was designed to evaluate the ability of gonadotropin releasing hormone (GnRh) agonist to prevent the rise of progesterone during controlled ovarian stimulation for in vitro fertilization (IVF) after the administration of human Chorionic Gonadotropin (hCG) on the first day of menses.
Detailed Description
The aim of this study is to evaluate the efficacy of a GnRH agonist in preventing the functional rescue of corpus luteum in women submitted to controlled ovarian stimulation with administration of hCG on the first day of menses and to evaluate its effect on pregnancy rate and ovarian steroidogenesis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age \>21 and \< 38 years old
- •polycystic ovarian syndrome
- •risk for ovarian hyperstimulation syndrome
Exclusion Criteria
- •recurrent abortion
- •endometriosis
- •more than 3 IVF failures
- •use of oral contraceptive pills in the preceding 3 months
- •low response to gonadotropins
Arms & Interventions
GnRH agonist
3,6 mg of goserelin acetate (GnRH agonist) will be administered on the 21st day of the menstrual cycle previous to ovarian stimulation. 250 mg of hCG will be administered on the first day of menses and a starting dose of 150 IU of FSH will be started 2 days later as a part of a long ovarian stimulation protocol. Ovulation will be triggered with a 250 mg of hCG when at least 2 follicles attain 18mm and to accommodate oocyte retrieval within 36 hours.
Intervention: GnRH agonist
Control
250 mg of hCG will be administered on the first day of menses and a starting dose of 150 IU of FSH will be started 2 days later as a part of a long ovarian stimulation protocol. Ovulation will be triggered with a 250 mg of hCG when at least 2 follicles attain 18mm and to accommodate oocyte retrieval within 36 hours.
Intervention: Control
Outcomes
Primary Outcomes
Frequency of functional rescue of corpus luteum
Time Frame: 6 months
Secondary Outcomes
- Pregnancy rate(6 months)
- Levels of serum steroids(6 months)
- Levels of serum gonadotropins(6 months)