NCT02908438UnknownPhase 1
Gonadotrophin Releasing Hormone Agonist Addition for Luteal Support in In-vitro Fertilization and Embryo Transfer Cycles
Northwest Women's and Children's Hospital, Xi'an, Shaanxi0 sites400 target enrollmentStarted: September 2016Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 1
- Sponsor
- Enrollment
- 400
- Primary Endpoint
- pregnancy rate
Study Overview
Brief Summary
The study was designed to investigate the effect of luteal-phase administration of gonadotrophin releasing hormone agonist(GnRHa) on pregnancy outcomes in in-vitro fertilization-embryo transfer.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 37 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age < 37 years;
- •One or more high quality embryos have been got in IVF/ICSI treatment;
- •To transfer at lest 2 fresh embryos;
- •Uterine endometrial thickness ≥ 7mm;
- •Patients have signed informed consents.
Exclusion Criteria
- •≥3 IVF/ICSI/FET cycles and no pregnancy;
- •Polycystic ovary syndrome(PCOS);
- •uterine malformation;
- •endometriosis
- •patients with a history of recurrent pregnancy loss.
Arms & Interventions
GnRHa group
Experimental
Intervention: additional GnRHa for routine LPS GnRHa group receive three injections of GnRHa(Decapeptyl) ,0.1 mg s.c. on the day of ET, and D3 and D6 after ET in addition to routine LPS.
Intervention: Gonadotrophin releasing hormone agonist(GnRHa) (Drug)
Outcomes
Primary Outcomes
pregnancy rate
Time Frame: up to 12 months
Secondary Outcomes
No secondary outcomes reported
Investigators
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